{"id":"W2147048440","doi":"10.1212/wnl.0b013e318228bf11","title":"A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease","year":2011,"lang":"en","type":"article","venue":"Neurology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Health Sciences, University of Arizona; National Institute on Aging; Medical Center, University of Rochester; University of California, Irvine; University of California, San Diego; University of California, Davis; Mitsubishi Tanabe Pharma Corporation; Elan; AstraZeneca; Genentech; University of Oxford; Baxter International; Lewy Body Dementia Association; National Center for Research Resources; National Alliance for Research on Schizophrenia and Depression; Myriad Genetics; SUNY Downstate Medical Center; Marinus Pharmaceuticals; Georgetown University; Demensförbundet; Otsuka Pharmaceutical; National Institutes of Health; BioMarin Pharmaceutical; Avid Radiopharmaceuticals; University of Pittsburgh; University of California, Los Angeles; Pfizer; University of Washington; U.S. Department of Defense; American Health Assistance Foundation; Eli Lilly and Company; State University of New York; University of Pennsylvania; University of South Carolina; Astellas Pharma; University of Southern California; Eisai; Medpace; Brown University; Daiichi Sankyo Europe; Yale University; Astellas Foundation for Research on Metabolic Disorders; Dainippon Sumitomo Pharma; Emory University; Alzheimer's Association; Brigham and Women's Hospital; York University; University of Rochester; Northwestern University; GlaxoSmithKline; Shire; Forest Laboratories; Bristol-Myers Squibb; Sanofi; Case Western Reserve University; American Federation for Aging Research; Rush University; Amgen","keywords":"Simvastatin; Medicine; Placebo; Randomized controlled trial; Double blind; Alzheimer's disease; Disease; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009666966,0.0001872929,0.001493739,0.0001719935,0.00003503607,0.000003517426,0.00009835768,0.0001139114,0.0003254175],"category_scores_gemma":[0.0002543414,0.0001299753,0.0007273646,0.0001330962,0.0001084146,0.00002713985,0.00004182223,0.0001915579,0.00006642702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006017058,"about_ca_system_score_gemma":0.0001858886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005267882,"about_ca_topic_score_gemma":0.00001765272,"domain_scores_codex":[0.9979284,0.0005333303,0.0005524141,0.0003543377,0.000314116,0.0003173379],"domain_scores_gemma":[0.9985366,0.0002028205,0.0001409613,0.0006153802,0.0001001238,0.0004040795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9956256,0.0004092359,0.00005080233,0.00002954097,0.0004431713,0.0001555843,0.0002394201,0.000006147129,0.00003253989,0.000391758,0.0001225182,0.002493653],"study_design_scores_gemma":[0.9936475,0.002999211,0.0001638571,0.000006538572,0.002013393,0.00002917066,0.000004128658,0.0000458778,0.0002912025,0.000107883,0.0005998458,0.0000913481],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788335,0.0004882534,0.0002198991,0.001480145,0.0004104579,0.01068076,0.000005027198,0.00004709481,0.007834872],"genre_scores_gemma":[0.9953395,0.00005617768,0.0001877905,0.002193732,0.0004069804,0.001605235,0.000008041945,0.00003195958,0.000170645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01650595,"threshold_uncertainty_score":0.5300241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0527985915358517,"score_gpt":0.3045996011236808,"score_spread":0.2518010095878291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}