{"id":"W2147048440","doi":"10.1212/wnl.0b013e318228bf11","title":"A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease","year":2011,"lang":"en","type":"article","venue":"Neurology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Health Sciences, University of Arizona; National Institute on Aging; Medical Center, University of Rochester; University of California, Irvine; University of California, San Diego; University of California, Davis; Mitsubishi Tanabe Pharma Corporation; Elan; AstraZeneca; Genentech; University of Oxford; Baxter International; Lewy Body Dementia Association; National Center for Research Resources; National Alliance for Research on Schizophrenia and Depression; Myriad Genetics; SUNY Downstate Medical Center; Marinus Pharmaceuticals; Georgetown University; Demensförbundet; Otsuka Pharmaceutical; National Institutes of Health; BioMarin Pharmaceutical; Avid Radiopharmaceuticals; University of Pittsburgh; University of California, Los Angeles; Pfizer; University of Washington; U.S. Department of Defense; American Health Assistance Foundation; Eli Lilly and Company; State University of New York; University of Pennsylvania; University of South Carolina; Astellas Pharma; University of Southern California; Eisai; Medpace; Brown University; Daiichi Sankyo Europe; Yale University; Astellas Foundation for Research on Metabolic Disorders; Dainippon Sumitomo Pharma; Emory University; Alzheimer's Association; Brigham and Women's Hospital; York University; University of Rochester; Northwestern University; GlaxoSmithKline; Shire; Forest Laboratories; Bristol-Myers Squibb; Sanofi; Case Western Reserve University; American Federation for Aging Research; Rush University; Amgen","keywords":"Simvastatin; Medicine; Placebo; Randomized controlled trial; Double blind; Alzheimer's disease; Disease; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002649253,0.001918907,0.004750642,0.0007519897,0.0008051371,0.001010115,0.0009577158,0.00280036,0.01255219],"category_scores_gemma":[0.003599438,0.0007734287,0.002083318,0.0005080589,0.001733953,0.001189738,0.0005887662,0.002216851,0.001453038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007222937,"about_ca_system_score_gemma":0.001762152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007116357,"about_ca_topic_score_gemma":0.001230704,"domain_scores_codex":[0.9981774,0.00103205,0.000183923,0.000288397,0.0001269623,0.0001911844],"domain_scores_gemma":[0.9987041,0.0003683562,0.0002747844,0.0001057093,0.000138921,0.0004081765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.99157,0.00213108,0.0001444528,0.0005035268,0.0004986269,0.00001585748,0.0000176245,0.00005751351,0.0007112048,0.0000582906,0.0003271439,0.003964627],"study_design_scores_gemma":[0.9914983,0.007863876,0.000200427,0.00001215279,0.0001320987,0.00000456583,0.000003972037,0.00005819097,0.00005747919,0.00003798128,0.0001282987,0.000002660669],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9543117,0.0103395,0.001392329,0.002685158,0.003159869,0.02144399,0.002076073,0.0003327798,0.004258594],"genre_scores_gemma":[0.9601687,0.004698963,0.002936876,0.00240718,0.001560125,0.02282031,0.001509117,0.00002704019,0.003871624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01255219,"threshold_uncertainty_score":0.04199129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0527985915358517,"score_gpt":0.3045996011236808,"score_spread":0.2518010095878291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}