{"id":"W2147055142","doi":"10.1111/acel.12402","title":"Homeostatic dysregulation proceeds in parallel in multiple physiological systems","year":2015,"lang":"en","type":"article","venue":"Aging Cell","topic":"Aging and Gerontology Research","field":"Psychology","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; Anatomical Society; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research","keywords":"Immune dysregulation; Disease; Biomarker; Biology; Immune system; Medicine; Immunology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005686893,0.0001016067,0.0002008484,0.0001643199,0.00002437764,0.00001682233,0.0001453644,0.0001141968,0.00002377804],"category_scores_gemma":[0.00005941631,0.00008879896,0.00001894688,0.0002385602,0.00006376637,0.0000571231,0.00003656615,0.0002577105,0.0003241742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007599891,"about_ca_system_score_gemma":0.00003200201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001262997,"about_ca_topic_score_gemma":0.0001446029,"domain_scores_codex":[0.9987131,0.0002536482,0.0002208086,0.0002887929,0.0001292656,0.0003943459],"domain_scores_gemma":[0.9995297,0.0001285307,0.00004835117,0.0001829453,0.00003577482,0.00007476121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000197315,0.0006064093,0.9624054,0.0001038287,0.00001556221,0.0001856279,0.02139443,0.003960012,0.0003581856,0.001220843,0.007838486,0.001713899],"study_design_scores_gemma":[0.004889924,0.0002327624,0.9409429,0.0000821179,0.00000599661,0.00002111716,0.01444663,0.03700123,0.00003401094,0.001108959,0.0009056064,0.0003287316],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880399,0.0009458461,0.000264145,0.0002276913,0.0002427324,0.0002698517,6.585084e-7,0.00005159154,0.009957608],"genre_scores_gemma":[0.9964831,0.000001780666,0.0001693098,0.00004879351,0.00005091229,0.0000808954,0.00001375163,0.00001127737,0.003140107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03304121,"threshold_uncertainty_score":0.4166711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1338669439957625,"score_gpt":0.3644733197829984,"score_spread":0.2306063757872359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}