{"id":"W2147058464","doi":"10.1200/jco.2004.04.188","title":"Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers: The PROSE Study Group","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Medicine; Prophylactic Mastectomy; Breast cancer; Prophylactic Surgery; Mastectomy; Oophorectomy; Cancer; BRCA mutation; Gynecology; Surgery; Germline mutation; Ovarian cancer; Oncology; Internal medicine; Hysterectomy; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009555329,0.0003355895,0.0004259124,0.0002537429,0.0001272474,0.0001954599,0.0001400576,0.0002337326,0.00083395],"category_scores_gemma":[0.001440282,0.0001404282,0.0003280506,0.000157784,0.000227849,0.0001731334,0.0002025923,0.0002211339,0.00005756529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001041474,"about_ca_system_score_gemma":0.0001686167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000537993,"about_ca_topic_score_gemma":0.0007724811,"domain_scores_codex":[0.999741,0.0001283542,0.00001292121,0.00004290656,0.00005309107,0.00002180562],"domain_scores_gemma":[0.9994949,0.0001473094,0.0002250386,0.00004335907,0.00002343754,0.00006588665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03162432,0.0006132154,0.9092895,0.0001959466,0.001527577,0.0003801078,0.0001108916,0.0005435529,0.004336532,0.00009187031,0.000434974,0.05085141],"study_design_scores_gemma":[0.001910063,0.008922986,0.9849948,0.00002849493,0.000705913,0.001093779,0.00006358864,0.0007823285,0.0008225603,0.0001147238,0.000551816,0.000008963514],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983925,0.001201074,0.00008855175,0.00005114606,0.000005866724,0.00001012487,0.00006961525,0.00000381881,0.0001773617],"genre_scores_gemma":[0.9992613,0.0003859668,0.00009789192,0.00002216411,0.00001313381,0.000006432279,0.00009627366,7.244973e-7,0.0001161452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009555329,"threshold_uncertainty_score":0.005053401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03248792481459869,"score_gpt":0.3905868678752462,"score_spread":0.3580989430606475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}