{"id":"W2147063219","doi":"10.1161/jaha.114.001156","title":"Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus","year":2014,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Diabetes, Cardiovascular Risks, and Lipoproteins","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; CSL Behring","keywords":"Choroid plexus; Cerebrospinal fluid; Central nervous system; Blood–brain barrier; Apolipoprotein B; Medicine; Apolipoprotein E; Lipoprotein; Endocrinology; Recombinant DNA; Internal medicine; Human brain; Pathology; Biology; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003167178,0.0001997985,0.0008331703,0.00008851122,0.0004878663,0.00009791369,0.0004106479,0.00007125385,0.000008373419],"category_scores_gemma":[0.0007167513,0.00009856909,0.0009817737,0.0004422039,0.0001689885,0.00009605151,0.00005897529,0.0007194062,0.00001270108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009387328,"about_ca_system_score_gemma":0.0001308677,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008488202,"about_ca_topic_score_gemma":0.0003885626,"domain_scores_codex":[0.9961131,0.001453187,0.0006352741,0.0001562528,0.001153509,0.0004887413],"domain_scores_gemma":[0.997479,0.0002385352,0.001228053,0.0005847113,0.0003281899,0.0001415434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.000858507,0.0007581602,0.3004797,0.0002699082,0.008400149,0.00003168787,0.009339249,0.001144685,0.04311959,0.0002831018,0.04236149,0.5929537],"study_design_scores_gemma":[0.001167226,0.0008468959,0.9764383,0.0001743532,0.000724997,0.0002950154,0.001444894,0.0002978123,0.002369406,0.00007219741,0.01602158,0.0001472594],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914086,0.0002611189,0.0004527478,0.00614528,0.0007300707,0.0006901769,0.000004182468,0.00003850602,0.0002692676],"genre_scores_gemma":[0.9953749,0.00002060271,0.0001128097,0.001788362,0.002453326,0.00001507786,0.00000215612,0.00003623949,0.0001965025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6759586,"threshold_uncertainty_score":0.9981143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005709532270492783,"score_gpt":0.2252720050192571,"score_spread":0.2195624727487643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}