{"id":"W2147063219","doi":"10.1161/jaha.114.001156","title":"Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus","year":2014,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Diabetes, Cardiovascular Risks, and Lipoproteins","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; CSL Behring","keywords":"Choroid plexus; Cerebrospinal fluid; Central nervous system; Blood–brain barrier; Apolipoprotein B; Medicine; Apolipoprotein E; Lipoprotein; Endocrinology; Recombinant DNA; Internal medicine; Human brain; Pathology; Biology; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738951,0.0004792602,0.0002541208,0.0002366777,0.0001255379,0.0004238526,0.0002017578,0.0002915398,0.001527174],"category_scores_gemma":[0.0002065493,0.00013133,0.0001744575,0.0001326806,0.0003681557,0.0003029174,0.0001218752,0.0007769509,0.0007151793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005803818,"about_ca_system_score_gemma":0.0005512063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001343157,"about_ca_topic_score_gemma":0.0009164845,"domain_scores_codex":[0.9998865,0.00001507002,0.000005594993,0.00004318224,0.00002657198,0.00002302023],"domain_scores_gemma":[0.9998569,0.00003933648,0.00004736747,0.00001525512,0.00001642454,0.00002470798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004868675,0.00007664715,0.0005556337,0.00007215841,0.00001486377,0.0002711191,0.00005227794,0.00005394184,0.9897204,0.0002012727,0.0003805962,0.008114134],"study_design_scores_gemma":[0.0001602998,0.004003448,0.006846775,0.00005054748,0.00004695494,0.001553296,0.00006803439,0.001450101,0.9780747,0.0001841984,0.007548063,0.00001356482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634743,0.00806099,0.0173903,0.0003982957,0.0001957477,0.0003717495,0.0004962042,0.001223513,0.008388969],"genre_scores_gemma":[0.9712927,0.003583878,0.01353061,0.0002475103,0.00007396466,0.0002566929,0.000591621,0.000100471,0.01032249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527174,"threshold_uncertainty_score":0.005108833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005709532270492783,"score_gpt":0.2252720050192571,"score_spread":0.2195624727487643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}