{"id":"W2147066049","doi":"10.1128/mcb.22.12.4241-4255.2002","title":"Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor Signaling","year":2002,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Jurkat cells; Signal transducing adaptor protein; Biology; Syk; Cell biology; Signal transduction; Molecular biology; SH3 domain; T cell; Proto-oncogene tyrosine-protein kinase Src; Tyrosine kinase; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359669,0.0006884139,0.0002703051,0.00038616,0.0003302053,0.0007180828,0.0006465483,0.0005248687,0.001129403],"category_scores_gemma":[0.0002724677,0.0002475843,0.0003870006,0.0002528804,0.0003439137,0.0002947502,0.0005378346,0.0007004541,0.0005762802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006580009,"about_ca_system_score_gemma":0.0004417714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006220755,"about_ca_topic_score_gemma":0.0009641768,"domain_scores_codex":[0.9995449,0.00007713548,0.00004216876,0.00006859002,0.0001411251,0.000126086],"domain_scores_gemma":[0.9998209,0.00002372622,0.0000427407,0.00002288768,0.00001961032,0.000070075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001386945,0.00002654235,0.0002968151,0.00004256006,0.000006609957,0.0002246893,0.000006574011,0.00006388783,0.9981554,0.0001673586,0.00006049027,0.000810258],"study_design_scores_gemma":[0.0001295857,0.0002394459,0.01709299,0.00001536931,0.0000469502,0.002973453,0.0000341728,0.003784616,0.9709615,0.0001720639,0.004530538,0.00001932714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864731,0.006746606,0.003153918,0.0002633727,0.00008727538,0.00004466458,0.0003571997,0.0001460565,0.00272787],"genre_scores_gemma":[0.9953884,0.0008268794,0.001336104,0.00007431985,0.00002965168,0.00004512957,0.000435572,0.0000105385,0.001853354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129403,"threshold_uncertainty_score":0.004774213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355026088486641,"score_gpt":0.1908904129786422,"score_spread":0.1773401520937758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}