{"id":"W2147093282","doi":"10.1128/jvi.79.10.6078-6088.2005","title":"Nuclear Localization of the Nipah Virus W Protein Allows for Inhibition of both Virus- and Toll-Like Receptor 3-Triggered Signaling Pathways","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virology and Viral Diseases","field":"Medicine","cited_by":197,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Cleveland Clinic; McGill University; Cleveland Clinic Foundation; Ellison Medical Foundation","keywords":"Biology; Nuclear localization sequence; Karyopherin; IRF3; TLR3; Signal transduction; Nuclear export signal; Nuclear transport; Cell biology; Molecular biology; Nuclear protein; Importin; Cytoplasm; Toll-like receptor; Cell nucleus; Receptor; Gene; Biochemistry; Transcription factor; Innate immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348316,0.0002706383,0.0001867343,0.00008213489,0.0001424954,0.0003051449,0.0001715812,0.0001943951,0.0007295113],"category_scores_gemma":[0.0001679939,0.0001115275,0.0002449123,0.00007960397,0.0002791444,0.0002578107,0.000242062,0.0004215154,0.0004019096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852964,"about_ca_system_score_gemma":0.0002485183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002889922,"about_ca_topic_score_gemma":0.0003834763,"domain_scores_codex":[0.9998608,0.00002577541,0.00001234027,0.00003117665,0.00003629937,0.00003350251],"domain_scores_gemma":[0.9998589,0.00002906199,0.00004434481,0.00002641727,0.00001380553,0.00002742899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000385706,0.000009040609,0.0001019624,0.00001432037,0.000002932278,0.00002932928,0.000005500392,0.00003880144,0.9990371,0.0001215336,0.0000105171,0.0005902179],"study_design_scores_gemma":[0.0000074359,0.00009833269,0.001172687,0.000004170342,0.000007567771,0.0001818002,0.00001222428,0.001093237,0.9956017,0.00005467629,0.001764085,0.000002148216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988135,0.001115924,0.008709912,0.00007876122,0.00002524148,0.00001289751,0.00009861466,0.0001240608,0.00169955],"genre_scores_gemma":[0.9953584,0.0003478882,0.002369072,0.0000232603,0.000005800258,0.00001373,0.0002507691,0.00002586301,0.001605177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007295113,"threshold_uncertainty_score":0.002440453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720981756880473,"score_gpt":0.2514832146019439,"score_spread":0.2342733970331392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}