{"id":"W2147132014","doi":"10.1128/mmbr.69.1.51-78.2005","title":"Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution","year":2005,"lang":"en","type":"review","venue":"Microbiology and Molecular Biology Reviews","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Science Foundation","keywords":"Biology; Carotenoid; Natural product; Computational biology; Chemical space; Synthetic biology; Directed evolution; Biochemistry; Drug discovery; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005480803,0.0008257665,0.00109308,0.001128189,0.0002610173,0.0009260887,0.0008526174,0.0006882305,0.001232977],"category_scores_gemma":[0.0003894243,0.0002749762,0.0003466714,0.00157164,0.0004244462,0.0008597072,0.0005975346,0.001114744,0.002416016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008355125,"about_ca_system_score_gemma":0.0005566109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007357359,"about_ca_topic_score_gemma":0.001062236,"domain_scores_codex":[0.9998121,0.00002985896,0.00001705465,0.00004092083,0.00008587583,0.00001420392],"domain_scores_gemma":[0.9999014,0.00003291054,0.00001912342,0.000007340938,0.000027907,0.00001137596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008751702,0.00007761398,0.0004840924,0.007501203,0.0001024348,0.0003872588,0.0001532738,0.001909308,0.04710924,0.01156221,0.008862063,0.9217638],"study_design_scores_gemma":[0.00003977755,0.0001557012,0.0008965689,0.0007853397,0.00009578442,0.00156977,0.00006289728,0.0005699194,0.01787734,0.003439629,0.9744772,0.00003009849],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002731163,0.9844614,0.004555021,0.0003222508,0.0002330396,0.00003020738,0.00003677386,0.00009509013,0.007535129],"genre_scores_gemma":[0.01043111,0.9784136,0.006836467,0.0002574329,0.00007806202,0.00004284395,0.000126119,0.00001736273,0.003797013],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001232977,"threshold_uncertainty_score":0.00606209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013345948930386,"score_gpt":0.2712862619091058,"score_spread":0.2511528024198019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}