{"id":"W2147142971","doi":"10.1093/hmg/ddt246","title":"Delayed myelination in a mouse model of fragile X syndrome","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; H. Lundbeck A/S","keywords":"Fragile X syndrome; FMR1; Oligodendrocyte; Biology; Myelin; Myelin basic protein; Cerebellum; Knockout mouse; White matter; Endocrinology; Glial fibrillary acidic protein; Internal medicine; Proteolipid protein 1; Neuroscience; Fragile x; Central nervous system; Genetics; Immunology; Magnetic resonance imaging; Receptor; Medicine; Gene; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006604936,0.000173036,0.0001510412,0.0001012275,0.00003607124,0.00001702059,0.0002306959,0.0001373118,0.00003201614],"category_scores_gemma":[0.00001395509,0.0001986206,0.00007318756,0.00009281482,0.00005292127,0.000002857663,0.0001436371,0.00007714293,0.00001438017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001151508,"about_ca_system_score_gemma":0.00004664979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002968163,"about_ca_topic_score_gemma":0.00003677305,"domain_scores_codex":[0.9988773,0.0000391555,0.0003314207,0.0003258389,0.0001808466,0.0002454718],"domain_scores_gemma":[0.9993863,0.000002277461,0.00008641602,0.0003543673,0.0001005282,0.00007014129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005448502,0.0001044902,0.0006128196,0.00001373927,0.00001908377,0.000002193075,0.00005350009,0.01665328,0.982011,0.0001154339,0.0001241124,0.0002849146],"study_design_scores_gemma":[0.001022595,0.0004755206,0.04858709,0.00001269537,0.00001524017,0.000006251114,0.00006631521,0.01491483,0.9320663,0.002253268,0.0001321872,0.0004476751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948556,0.0003591207,0.003819115,0.00002977409,0.00002338285,0.0003361827,0.00001774103,0.000007229665,0.0005518295],"genre_scores_gemma":[0.9953326,0.0001427008,0.00375793,0.0001976403,0.000003679448,0.00005295372,0.0001287442,0.00004161024,0.000342158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04994465,"threshold_uncertainty_score":0.8099514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081781430348904,"score_gpt":0.2293088940293412,"score_spread":0.2184910797258522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}