{"id":"W2147142971","doi":"10.1093/hmg/ddt246","title":"Delayed myelination in a mouse model of fragile X syndrome","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; H. Lundbeck A/S","keywords":"Fragile X syndrome; FMR1; Oligodendrocyte; Biology; Myelin; Myelin basic protein; Cerebellum; Knockout mouse; White matter; Endocrinology; Glial fibrillary acidic protein; Internal medicine; Proteolipid protein 1; Neuroscience; Fragile x; Central nervous system; Genetics; Immunology; Magnetic resonance imaging; Receptor; Medicine; Gene; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004817377,0.001628452,0.0006767694,0.001705546,0.0006120297,0.0006409395,0.0008311215,0.002100951,0.004637853],"category_scores_gemma":[0.000269702,0.0005139988,0.0008203416,0.000484985,0.0008013104,0.0005924352,0.0006171039,0.002190337,0.001218017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000760952,"about_ca_system_score_gemma":0.0005713378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001183005,"about_ca_topic_score_gemma":0.001577493,"domain_scores_codex":[0.9994195,0.00007044364,0.0000726738,0.0002057665,0.0001352151,0.00009641056],"domain_scores_gemma":[0.9995089,0.00004545663,0.0002018895,0.0000539814,0.00003727664,0.0001525129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009142398,0.0006701887,0.000482491,0.0001414615,0.00004858548,0.0009828947,0.000158403,0.0002653432,0.9915221,0.001300796,0.0004837827,0.003029671],"study_design_scores_gemma":[0.0007121236,0.0101892,0.01241832,0.0002573637,0.0002983465,0.00680766,0.0003247215,0.004630023,0.9356599,0.001602434,0.02700039,0.00009937702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766654,0.003067686,0.00908279,0.0009948778,0.0003725697,0.0004306237,0.004150892,0.001464958,0.003770324],"genre_scores_gemma":[0.947588,0.004616646,0.01325531,0.0005224208,0.00009927917,0.001776084,0.003996283,0.0002789844,0.02786697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004637853,"threshold_uncertainty_score":0.01551521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01081781430348904,"score_gpt":0.2293088940293412,"score_spread":0.2184910797258522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}