{"id":"W2147147806","doi":"10.1124/dmd.105.004374","title":"CANCER CHEMOTHERAPY AND DRUG METABOLISM","year":2005,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute","keywords":"Prodrug; Pharmacology; Drug metabolism; Drug; Pharmacokinetics; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000764644,0.0004582773,0.0005589532,0.0002091685,0.0004899491,0.00009712849,0.0002154965,0.000214263,0.0009624621],"category_scores_gemma":[0.0000168699,0.0004201404,0.0001260809,0.0002520512,0.0002910327,0.0004521349,0.0001215,0.0005692368,0.00006074031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000232908,"about_ca_system_score_gemma":0.00005498061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001339178,"about_ca_topic_score_gemma":0.0000481514,"domain_scores_codex":[0.9976182,0.0003979745,0.0004652075,0.000628611,0.0002607618,0.0006292547],"domain_scores_gemma":[0.9987845,0.0001311394,0.0001808755,0.0002336695,0.000113053,0.0005567126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007236622,0.0006191459,0.002545753,0.000103438,0.0004806918,0.00001488921,0.007493629,0.0002815246,0.18923,0.02034566,0.01677905,0.7613826],"study_design_scores_gemma":[0.004257454,0.000006635145,0.03247244,0.00001438873,0.0007254515,0.00002661183,0.0001594763,0.002372362,0.1081315,0.001384561,0.849869,0.0005801381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8918064,0.09599064,0.00009148438,0.007242091,0.001382587,0.0004661233,0.0002582666,0.0001279373,0.002634519],"genre_scores_gemma":[0.9402167,0.04393698,0.0006811706,0.01080367,0.002167078,0.0001510783,0.00005782356,0.00005864775,0.001926829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8330899,"threshold_uncertainty_score":0.9999508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03125667228027106,"score_gpt":0.3759516955180336,"score_spread":0.3446950232377626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}