{"id":"W2147178056","doi":"10.1093/intimm/dxh377","title":"B cell proliferation following CD40 stimulation results in the expression and activation of Src protein tyrosine kinase","year":2006,"lang":"en","type":"article","venue":"International Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Toronto General Hospital; Héma-Québec","funders":"University of Calgary","keywords":"Proto-oncogene tyrosine-protein kinase Src; CD154; Tyrosine kinase; Molecular biology; Biology; Cell growth; Transfection; Tyrosine-protein kinase CSK; Cell biology; Cell culture; Kinase; CD40; Chemistry; Signal transduction; SH3 domain; Biochemistry; Cytotoxic T cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003812099,0.0001677712,0.0002116665,0.0002694897,0.000122031,0.00002105994,0.0002785475,0.0002982111,0.00004797601],"category_scores_gemma":[0.0001198264,0.000130818,0.00006326185,0.0001530181,0.0001645977,0.0002340325,0.00009022946,0.000310687,0.00003052987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005434682,"about_ca_system_score_gemma":0.00003496022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004525879,"about_ca_topic_score_gemma":0.0000240627,"domain_scores_codex":[0.9984981,0.0003313931,0.0005748516,0.0002995091,0.00007537418,0.0002208087],"domain_scores_gemma":[0.999127,0.0002200597,0.0003069012,0.0002317778,0.0001095405,0.000004683613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006787149,0.0003569551,0.001556874,0.0000075597,0.0000363654,0.000006355313,0.0003667935,0.0001043841,0.994012,0.001628828,0.0003771094,0.0008680364],"study_design_scores_gemma":[0.003838065,0.0002363708,0.01352665,0.00007216867,0.000013295,0.00002965975,0.0002332976,0.00007016704,0.9771941,0.001515511,0.003131664,0.0001390036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933734,0.0009962503,0.0004019747,0.001134387,0.0005226691,0.0004822319,0.00001709193,0.00003038696,0.003041635],"genre_scores_gemma":[0.9974474,0.00002037074,0.0001811917,0.00006400963,0.00004640415,0.00007240722,0.0005507637,0.00001164885,0.001605767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01681788,"threshold_uncertainty_score":0.5334604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003353020312373,"score_gpt":0.2350012600687246,"score_spread":0.2249677298656009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}