{"id":"W2147178056","doi":"10.1093/intimm/dxh377","title":"B cell proliferation following CD40 stimulation results in the expression and activation of Src protein tyrosine kinase","year":2006,"lang":"en","type":"article","venue":"International Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Toronto General Hospital; Héma-Québec","funders":"University of Calgary","keywords":"Proto-oncogene tyrosine-protein kinase Src; CD154; Tyrosine kinase; Molecular biology; Biology; Cell growth; Transfection; Tyrosine-protein kinase CSK; Cell biology; Cell culture; Kinase; CD40; Chemistry; Signal transduction; SH3 domain; Biochemistry; Cytotoxic T cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708451,0.0003407211,0.0002669221,0.0004046242,0.0002051837,0.0002754571,0.0001064887,0.0002442177,0.003262311],"category_scores_gemma":[0.0001118382,0.0001628389,0.0002321864,0.0003234787,0.0001783293,0.0001355956,0.0002090746,0.0006202189,0.00137016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394082,"about_ca_system_score_gemma":0.0001912029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004233013,"about_ca_topic_score_gemma":0.0006631242,"domain_scores_codex":[0.9997463,0.00003890185,0.00001597427,0.00003019137,0.00009839085,0.00007022925],"domain_scores_gemma":[0.999821,0.00005072192,0.00002227696,0.00002507376,0.00002761066,0.00005329469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008000003,0.00003879044,0.0001128179,0.00003759186,0.000002425423,0.00005317925,0.00001452624,0.00001605325,0.9983035,0.00006056229,0.00004784771,0.001232737],"study_design_scores_gemma":[0.0000146216,0.0003639954,0.007046394,0.000006745659,0.00001091417,0.0003799635,0.00002380433,0.0002762289,0.9882583,0.00006314051,0.003552237,0.000003629648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860907,0.00324489,0.00217909,0.00008083111,0.00006510001,0.0000473311,0.0006141135,0.0001352628,0.007542632],"genre_scores_gemma":[0.9846076,0.002517895,0.002614517,0.00006191439,0.00005464207,0.0001017231,0.00199186,0.00002547265,0.008024266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003262311,"threshold_uncertainty_score":0.01091349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003353020312373,"score_gpt":0.2350012600687246,"score_spread":0.2249677298656009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}