{"id":"W2147186597","doi":"10.1158/1535-7163.mct-12-1166","title":"PRIMA-1Met/APR-246 Displays High Antitumor Activity in Multiple Myeloma By Induction of p73 and Noxa","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Moffitt Cancer Center","keywords":"Multiple myeloma; Apoptosis; Dexamethasone; Cancer research; Gene knockdown; In vivo; Gene silencing; Cell culture; Doxorubicin; Chemistry; Medicine; Biology; Immunology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009473535,0.0001960318,0.0003694488,0.0001011377,0.00003989039,0.00002010795,0.00007385432,0.0001228888,0.0001096573],"category_scores_gemma":[0.000005844032,0.0001773115,0.00006475877,0.0002341398,0.00009236372,0.0001099388,0.00003116123,0.0002169961,0.000003114901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300243,"about_ca_system_score_gemma":0.00008663585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002631068,"about_ca_topic_score_gemma":0.0001226578,"domain_scores_codex":[0.9989215,0.00004755087,0.0002218351,0.0003030241,0.000247892,0.0002581955],"domain_scores_gemma":[0.9993819,0.00002079476,0.0001243857,0.0002911141,0.0000977747,0.00008403139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002014384,0.0001756548,0.004602395,0.00007809603,0.000117315,0.000008052591,0.0001898354,0.000009763952,0.9161077,0.0001861072,0.00005957069,0.07826403],"study_design_scores_gemma":[0.003136856,0.000350049,0.06784117,0.0001156158,0.00009430216,0.00001102806,0.00006212184,0.0009083123,0.9236659,0.0005779108,0.003011836,0.0002249135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912427,0.003190099,0.003285001,0.001296703,0.0002114083,0.0006478342,0.00003248397,0.00002503415,0.00006873988],"genre_scores_gemma":[0.9967654,0.001193191,0.0006406422,0.001052178,0.00005470031,0.0001091829,0.00001248633,0.00004378796,0.0001284763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07803912,"threshold_uncertainty_score":0.7230552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821987219354484,"score_gpt":0.2682079650606845,"score_spread":0.2499880928671396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}