{"id":"W2147195750","doi":"10.1084/jem.20040394","title":"Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions","year":2004,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":319,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Memorial Sloan-Kettering Cancer Center","keywords":"Notch signaling pathway; Biology; Stromal cell; Cell biology; T cell; CD8; Progenitor cell; Cellular differentiation; Lineage (genetic); IL-2 receptor; Stem cell; Immunology; Signal transduction; Cancer research; Antigen; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001812367,0.0001745833,0.0001931946,0.0001757199,0.000211947,0.0007247992,0.0002444842,0.0001716399,0.000535365],"category_scores_gemma":[0.0002815996,0.000194972,0.0001723433,0.0001741002,0.0001825061,0.0002712878,0.0004542663,0.000434958,0.0004465218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003412324,"about_ca_system_score_gemma":0.0003062574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00064819,"about_ca_topic_score_gemma":0.001817185,"domain_scores_codex":[0.9996961,0.0000428648,0.00002744258,0.00004777119,0.00009530172,0.00009056253],"domain_scores_gemma":[0.9997913,0.00002726336,0.00004877855,0.00004803798,0.00003142486,0.00005312261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002789365,0.000007453024,0.0004186545,0.000005655111,0.000001500721,0.00003804199,0.00001444582,0.00002969284,0.9984637,0.000076538,0.000008553853,0.0009077512],"study_design_scores_gemma":[0.00001356663,0.0002020847,0.01435189,0.000006495734,0.00001929136,0.0006756102,0.00008933189,0.001268006,0.9807758,0.0001010619,0.00249183,0.000005003541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975317,0.0004060098,0.001147168,0.00001833411,0.000002998335,0.000004542426,0.00003531809,0.00002035285,0.0008335781],"genre_scores_gemma":[0.9973787,0.0002719393,0.001089887,0.00001470387,0.000005312383,0.000007906556,0.000233061,0.0000115857,0.0009868921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007247992,"threshold_uncertainty_score":0.002475858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974593680520331,"score_gpt":0.2707849407598582,"score_spread":0.2510390039546548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}