{"id":"W2147195750","doi":"10.1084/jem.20040394","title":"Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions","year":2004,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":319,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Memorial Sloan-Kettering Cancer Center","keywords":"Notch signaling pathway; Biology; Stromal cell; Cell biology; T cell; CD8; Progenitor cell; Cellular differentiation; Lineage (genetic); IL-2 receptor; Stem cell; Immunology; Signal transduction; Cancer research; Antigen; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002446523,0.0001047939,0.0002403074,0.00008956426,0.00009490602,0.000002528569,0.0001499655,0.00005682935,0.0002513476],"category_scores_gemma":[0.00003817942,0.00005991731,0.00004060853,0.0000701682,0.0004107668,0.00008788129,0.00003766415,0.0002499607,0.00001743789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006391799,"about_ca_system_score_gemma":0.00002022375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004828031,"about_ca_topic_score_gemma":0.000004667139,"domain_scores_codex":[0.9991596,0.0001134779,0.0004735098,0.00008050287,0.0000511346,0.0001217593],"domain_scores_gemma":[0.9991289,0.0001083382,0.0005240701,0.000132208,0.00008863382,0.00001782802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005532288,0.0002638156,0.00005672108,0.000007261342,0.00005594785,7.398311e-7,0.003936506,0.000001396822,0.992838,0.0003314584,0.001265903,0.0006890149],"study_design_scores_gemma":[0.002574029,0.001251815,0.0006790771,0.0001946593,0.00005314014,0.0002029491,0.005367922,5.708847e-7,0.986722,0.0001974115,0.002700957,0.00005546165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800462,0.01580901,0.0003097247,0.001677074,0.001589054,0.0001023778,0.000002460513,0.000005229346,0.0004589428],"genre_scores_gemma":[0.9974216,0.001957857,0.00007008632,0.00005087437,0.0001015067,0.000001801281,0.00001030539,0.000006772123,0.0003791782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0173755,"threshold_uncertainty_score":0.275208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974593680520331,"score_gpt":0.2707849407598582,"score_spread":0.2510390039546548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}