{"id":"W2147205113","doi":"10.1093/hmg/ddu142","title":"Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Laurentian University; Ottawa Hospital","funders":"Multiple Sclerosis Society of Canada; Canadian Institutes of Health Research; Multiple Sclerosis Society; University of Ottawa; Muscular Dystrophy Association","keywords":"Spinal muscular atrophy; SMA*; SMN1; Biology; Motor neuron; Myocyte; Trichostatin A; Muscle atrophy; Atrophy; Pathogenesis; Neuroscience; Endocrinology; Histone deacetylase; Spinal cord; Immunology; Genetics; Gene; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001103227,0.0002925015,0.0002118118,0.0004030765,0.0001436166,0.0002050978,0.000113067,0.0002186826,0.0008009375],"category_scores_gemma":[0.00008865113,0.0001043366,0.0001229253,0.0001663786,0.0002616492,0.0001120819,0.0002507076,0.0002705865,0.0001447417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001808595,"about_ca_system_score_gemma":0.0001544435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003606595,"about_ca_topic_score_gemma":0.0009005354,"domain_scores_codex":[0.9998969,0.00001802078,0.000009925787,0.0000317944,0.00002881109,0.0000145988],"domain_scores_gemma":[0.9999192,0.000007789036,0.00003745286,0.000006484275,0.00000919739,0.00001989152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001542461,0.00002704059,0.005789786,0.0000680021,0.00001535098,0.0003531496,0.00002889968,0.00005524842,0.9897665,0.0001018462,0.00004517234,0.003594823],"study_design_scores_gemma":[0.00002936462,0.001190549,0.4085087,0.00006370959,0.0002009392,0.006720118,0.0002432455,0.001190669,0.5743089,0.0004607028,0.007071098,0.00001208269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938017,0.004025814,0.001137953,0.00006816911,0.00001310941,0.00001052732,0.0001138198,0.00003138174,0.0007975559],"genre_scores_gemma":[0.9954631,0.002662487,0.0006666235,0.00002825065,0.000009727531,0.00001141062,0.000173963,0.000005764933,0.0009787451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008009375,"threshold_uncertainty_score":0.002679408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01558883808945921,"score_gpt":0.3295255465681211,"score_spread":0.3139367084786619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}