{"id":"W2147238518","doi":"10.1371/journal.pntd.0001012","title":"Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica","year":2011,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Helminth infection and control","field":"Veterinary","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; International Union of Biochemistry and Molecular Biology; Cancer Australia; Natural Sciences and Engineering Research Council of Canada; Universidad de la República Uruguay; Australian Government","keywords":"Fasciola; Biology; Fasciola hepatica; Secretion; Virulence; Cathepsin L; Cathepsin; Pathogen; Microbiology; Biochemistry; Entamoeba histolytica; Enzyme; Helminths; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001294399,0.0002416578,0.00007275464,0.00007543278,0.00007392727,0.0001970989,0.0001253159,0.0001637093,0.0006206544],"category_scores_gemma":[0.0001790816,0.00006329495,0.0002380203,0.0000858038,0.0001100748,0.0001165007,0.00007855849,0.0001694969,0.000112088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003159501,"about_ca_system_score_gemma":0.000165017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009754187,"about_ca_topic_score_gemma":0.0008179745,"domain_scores_codex":[0.9999393,0.00001074354,0.000003798518,0.00001030602,0.00001604364,0.00001970906],"domain_scores_gemma":[0.9999226,0.00002135909,0.00002635602,0.000002717104,0.000009628139,0.00001731884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006115995,0.00007976019,0.01121579,0.0001816309,0.00005095833,0.0002596042,0.00006473867,0.003033556,0.9809083,0.0001959192,0.00008959592,0.003308512],"study_design_scores_gemma":[0.00009355905,0.0008250367,0.05137764,0.00002718826,0.00006766581,0.001423369,0.0001530963,0.03055479,0.9128228,0.0002235736,0.002406094,0.00002510226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988734,0.000343014,0.0004101504,0.00001265891,0.000001569018,0.000004336355,0.00009510486,0.00000378461,0.0002560664],"genre_scores_gemma":[0.9986934,0.0001829132,0.0006158027,0.000006327913,9.100813e-7,0.000005581036,0.0002739912,0.000001726916,0.0002192952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009754187,"threshold_uncertainty_score":0.002292395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04635713165184692,"score_gpt":0.2517118182800293,"score_spread":0.2053546866281824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}