{"id":"W2147257015","doi":"10.1186/s12977-015-0197-x","title":"Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production","year":2015,"lang":"en","type":"article","venue":"Retrovirology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; Cambridge Institute for Medical Research, University of Cambridge; Medical Research Council; Universitetet i Oslo; McGill University","keywords":"ESCRT; Endosome; Cell biology; Gene knockdown; TSG101; Biology; Viral entry; Mutant; Virology; Virus; Intracellular; Cell culture; Viral replication; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041465,0.0002899487,0.0003302471,0.00006958341,0.0008427741,0.00001808287,0.0004111168,0.0003065463,0.00002137646],"category_scores_gemma":[0.0002157593,0.0002409707,0.0003102666,0.0001228908,0.0003244077,0.00001627648,0.00007357279,0.0001378197,0.000003807335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004907854,"about_ca_system_score_gemma":0.0001158643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006332092,"about_ca_topic_score_gemma":0.0001107222,"domain_scores_codex":[0.9977363,0.00008440104,0.0005387278,0.0007861688,0.0002516417,0.0006028042],"domain_scores_gemma":[0.9986144,0.00003147778,0.0003754934,0.0006661264,0.0002180195,0.00009446972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000948646,0.0001324666,0.003279493,0.00004851495,0.00004883299,0.000001398635,0.0009905447,0.000373725,0.9929526,0.0002903387,0.0004592753,0.0004742062],"study_design_scores_gemma":[0.005051197,0.008858346,0.01440482,0.0001092507,0.0005133388,0.0001022602,0.0008624712,0.004972961,0.8053609,0.0009402383,0.1576226,0.001201647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9399619,0.001625851,0.05479499,0.001621883,0.0004772361,0.001290623,0.00007916871,0.00004510433,0.0001032814],"genre_scores_gemma":[0.9951705,0.00008683344,0.0005492105,0.00032085,0.0004942497,0.0002357855,0.002353775,0.00004804877,0.000740701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1875917,"threshold_uncertainty_score":0.98265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08578250582603977,"score_gpt":0.2936922892699589,"score_spread":0.2079097834439191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}