{"id":"W2147257015","doi":"10.1186/s12977-015-0197-x","title":"Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production","year":2015,"lang":"en","type":"article","venue":"Retrovirology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; Cambridge Institute for Medical Research, University of Cambridge; Medical Research Council; Universitetet i Oslo; McGill University","keywords":"ESCRT; Endosome; Cell biology; Gene knockdown; TSG101; Biology; Viral entry; Mutant; Virology; Virus; Intracellular; Cell culture; Viral replication; Biochemistry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009913524,0.0002833056,0.000139232,0.0001703144,0.0001413838,0.0003232069,0.000232524,0.0003325133,0.00187292],"category_scores_gemma":[0.0001437636,0.0001042187,0.0002345561,0.0001032647,0.0001866074,0.000202243,0.0002080455,0.0004587465,0.0005816128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002333709,"about_ca_system_score_gemma":0.0001961095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005181059,"about_ca_topic_score_gemma":0.0005293944,"domain_scores_codex":[0.9999118,0.000006143453,0.00001509658,0.00002072186,0.0000341778,0.00001197214],"domain_scores_gemma":[0.999809,0.00002995456,0.00005844003,0.00002789511,0.00003694994,0.0000379163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003093876,0.00001155197,0.0003032335,0.00004731895,0.000005490986,0.00008836736,0.000004147479,0.00001591642,0.9988289,0.00008128385,0.00004884872,0.0005339443],"study_design_scores_gemma":[0.00001144896,0.0001040997,0.02058493,0.00001785433,0.00004540817,0.00202178,0.00002589018,0.0005113552,0.9714797,0.0001033792,0.005088973,0.000005044723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982103,0.005905415,0.005144411,0.000302012,0.000109919,0.00003045054,0.001602702,0.0001187093,0.004683401],"genre_scores_gemma":[0.987435,0.002254266,0.003751189,0.0001638694,0.00002273709,0.00002685115,0.002947236,0.00004433505,0.003354513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00187292,"threshold_uncertainty_score":0.006265581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08578250582603977,"score_gpt":0.2936922892699589,"score_spread":0.2079097834439191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}