{"id":"W2147270226","doi":"10.1096/fj.15-270579","title":"Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting","year":2015,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research","keywords":"Deubiquitinating enzyme; Ubiquitin; Muscle atrophy; Wasting; Atrophy; Skeletal muscle; Endocrinology; Protein degradation; Internal medicine; Chemistry; Myocyte; Denervation; Protease; Cachexia; Cell biology; Enzyme; Biology; Biochemistry; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007817087,0.0001145089,0.0001009354,0.00002584864,0.0003364885,0.00002368461,0.0003201758,0.00007971825,0.00000818623],"category_scores_gemma":[0.0005632142,0.00006880912,0.00009278423,0.0001114457,0.0001469418,0.000009525176,0.0001421022,0.0002908868,0.000002419335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000250139,"about_ca_system_score_gemma":0.0001894518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007197761,"about_ca_topic_score_gemma":0.000003677389,"domain_scores_codex":[0.9989179,0.0003023539,0.0002407952,0.0001428857,0.0001820425,0.0002140017],"domain_scores_gemma":[0.9991117,0.00002774081,0.0003343081,0.0002672911,0.0001722155,0.00008679111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009832965,0.00004295693,0.0003341727,0.00001466411,0.00001779762,0.000001245829,0.0003313326,0.001026425,0.9920657,0.0001067597,0.0007323206,0.005228294],"study_design_scores_gemma":[0.0007105217,0.0001644537,0.00204891,0.00006911987,0.000006976165,0.00003666637,0.001275067,0.0001765548,0.9926432,0.0007644827,0.001992482,0.0001115544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955932,0.000445744,0.001385625,0.0003808397,0.0001499516,0.0003235318,0.000003879405,0.000006787022,0.001710409],"genre_scores_gemma":[0.9989352,0.00003237883,0.0002114884,0.0003339073,0.0003750037,0.00002116827,0.000007832066,0.00001393391,0.00006907332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005116739,"threshold_uncertainty_score":0.2805955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02776844357226058,"score_gpt":0.2467045304908747,"score_spread":0.2189360869186141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}