{"id":"W2147304052","doi":"10.1016/j.thromres.2014.12.010","title":"Thrombin Generation Potential and Whole-Blood DNA methylation","year":2014,"lang":"en","type":"letter","venue":"Thrombosis Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Epigenetics; Genome-wide association study; Methylation; Promoter; Biology; Von Willebrand factor; Genetics; Gene; Missing heritability problem; Coagulation; Bioinformatics; Molecular biology; Gene expression; Medicine; Single-nucleotide polymorphism; Immunology; Internal medicine; Platelet; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001686512,0.0003199308,0.0003443514,0.0002672038,0.0003617384,0.0002305817,0.0003172267,0.001353908,0.00006519491],"category_scores_gemma":[0.0002137041,0.0003208251,0.0001222387,0.0001932862,0.0002698415,0.00000852243,0.0002909565,0.001078971,0.00006115141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003166624,"about_ca_system_score_gemma":0.000124967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007540852,"about_ca_topic_score_gemma":0.00002607511,"domain_scores_codex":[0.9961809,0.001032678,0.000380853,0.0009162819,0.0008828085,0.0006064884],"domain_scores_gemma":[0.998466,0.00006685535,0.0001395798,0.0007452994,0.000482303,0.0001000239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005277585,0.00002568931,0.00004410069,0.00004916523,0.0001116609,0.000003808766,0.00002346537,0.00001595469,0.7301374,0.00001537206,0.2686084,0.0009596657],"study_design_scores_gemma":[0.0005536072,0.000610731,0.0009281851,0.00002588046,0.0001031681,0.000006726902,0.00001000477,0.0003759789,0.5331042,0.0007397713,0.4631152,0.0004264741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7702193,0.006199524,0.004737698,0.2139244,0.000681088,0.001279012,0.0001097552,0.00004904267,0.002800151],"genre_scores_gemma":[0.9073871,0.007281056,0.001639519,0.0430656,0.02228327,0.0002277328,0.01266829,0.0003051228,0.00514236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1970332,"threshold_uncertainty_score":0.9999425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09797867137609356,"score_gpt":0.3686924283526988,"score_spread":0.2707137569766053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}