{"id":"W2147329075","doi":"10.1093/aje/kwr368","title":"Gene-Environment Interactions in Genome-Wide Association Studies: A Comparative Study of Tests Applied to Empirical Studies of Type 2 Diabetes","year":2011,"lang":"en","type":"article","venue":"American Journal of Epidemiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; National Human Genome Research Institute; Canadian Institutes of Health Research; National Institute on Drug Abuse; U.S. Public Health Service; Broad Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Brigham and Women's Hospital; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; Massachusetts Institute of Technology; National Institutes of Health","keywords":"Genome-wide association study; Bayes' theorem; Context (archaeology); Statistics; Type I and type II errors; Genetic association; Logistic regression; Population; Econometrics; Medicine; Genetics; Biology; Mathematics; Bayesian probability; Gene; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.3116456,0.001562792,0.002936391,0.008648748,0.001003945,0.004676932,0.003235042,0.003340271,0.001679827],"category_scores_gemma":[0.6459363,0.0006599114,0.004737601,0.01190738,0.007610287,0.004394681,0.004037984,0.002544672,0.0001626013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002213865,"about_ca_system_score_gemma":0.002178901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001951784,"about_ca_topic_score_gemma":0.001755476,"domain_scores_codex":[0.4344513,0.535374,0.00984769,0.0069017,0.01254844,0.0008768466],"domain_scores_gemma":[0.06523187,0.9196779,0.005258017,0.005995282,0.003479653,0.0003574163],"domain_codex":"methods","domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.006198765,0.0005629797,0.366722,0.006217969,0.02410739,0.0009188493,0.007611853,0.02404512,0.001796729,0.0540117,0.002587748,0.5052188],"study_design_scores_gemma":[0.002692708,0.01307496,0.5796621,0.004988557,0.01074893,0.003403354,0.007594391,0.2107998,0.004217082,0.1449371,0.01701359,0.0008674084],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4664779,0.1191866,0.38991,0.008301773,0.001399024,0.00079199,0.0004865494,0.0005997533,0.01284646],"genre_scores_gemma":[0.9092618,0.00531805,0.08241757,0.001294178,0.0004986542,0.0005452199,0.0001777637,0.0001664413,0.0003204084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3116456,"threshold_uncertainty_score":0.8488636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1257722217182218,"score_gpt":0.3998828774665452,"score_spread":0.2741106557483233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}