{"id":"W2147360810","doi":"10.1016/j.ajpath.2011.01.044","title":"Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism","year":2011,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Servier; Canadian Diabetes Association; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Vorinostat; Enos; Diabetic nephropathy; Pharmacology; Oxidative stress; Nephropathy; Endocrinology; Nitric oxide synthase; Histone deacetylase; Nitric Oxide Synthase Type III; Peroxynitrite; Histone deacetylase inhibitor; Nitric oxide; Internal medicine; Medicine; Diabetes mellitus; Chemistry; Histone; Biochemistry; Superoxide; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002560374,0.0004236,0.0007625308,0.0002465951,0.0002445709,0.0004098848,0.0004037241,0.0003547041,0.001382205],"category_scores_gemma":[0.0002426554,0.0001752095,0.0003767133,0.0001998413,0.0005192257,0.000585133,0.000188798,0.001828763,0.0002496642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003821882,"about_ca_system_score_gemma":0.0006832324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006149222,"about_ca_topic_score_gemma":0.002320993,"domain_scores_codex":[0.9998831,0.00001670016,0.00001129048,0.00001412313,0.00002547962,0.00004926669],"domain_scores_gemma":[0.9997377,0.00002074763,0.00005960785,0.00003504425,0.00002248424,0.0001243899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02239534,0.002527467,0.001042152,0.0001580801,0.0001215764,0.0001957296,0.00005640917,0.000248148,0.9525684,0.0004522259,0.0008168993,0.0194176],"study_design_scores_gemma":[0.0034489,0.01930797,0.03215103,0.00004589413,0.0003736643,0.0003445245,0.000237468,0.003178094,0.9351161,0.0006385855,0.005107296,0.00005047421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941859,0.002889119,0.001104144,0.0004275479,0.0002770979,0.00002331126,0.0001663431,0.0001607353,0.0007656751],"genre_scores_gemma":[0.9949934,0.00141528,0.0007645444,0.0001173471,0.0001009403,0.00005614291,0.0003560826,0.00001561395,0.00218074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382205,"threshold_uncertainty_score":0.00462395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663114874672492,"score_gpt":0.2993458072162923,"score_spread":0.2827146584695674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}