{"id":"W2147360810","doi":"10.1016/j.ajpath.2011.01.044","title":"Long-Term Administration of the Histone Deacetylase Inhibitor Vorinostat Attenuates Renal Injury in Experimental Diabetes through an Endothelial Nitric Oxide Synthase-Dependent Mechanism","year":2011,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Servier; Canadian Diabetes Association; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Vorinostat; Enos; Diabetic nephropathy; Pharmacology; Oxidative stress; Nephropathy; Endocrinology; Nitric oxide synthase; Histone deacetylase; Nitric Oxide Synthase Type III; Peroxynitrite; Histone deacetylase inhibitor; Nitric oxide; Internal medicine; Medicine; Diabetes mellitus; Chemistry; Histone; Biochemistry; Superoxide; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005044043,0.0002193844,0.0004084031,0.0001692877,0.0000672426,0.00000894768,0.0004496395,0.0001235518,0.00003077073],"category_scores_gemma":[0.0001644272,0.0001779799,0.0001767688,0.0001986494,0.0007128542,0.00003391201,0.0001479866,0.0003348218,0.000003885229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009278279,"about_ca_system_score_gemma":0.0002963588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000702769,"about_ca_topic_score_gemma":0.00005104188,"domain_scores_codex":[0.9976389,0.0006283018,0.0007011016,0.0003181718,0.0003418197,0.0003716777],"domain_scores_gemma":[0.9985341,0.00003220887,0.0007293602,0.0004026041,0.0001731648,0.0001285273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008656699,0.000596065,0.009506864,0.000008403492,0.00003476686,0.0002885619,0.0004992056,0.000002526607,0.9869431,0.00004133258,0.00003128901,0.001182215],"study_design_scores_gemma":[0.0007612823,0.004341632,0.009074694,0.00003773301,0.00002527589,0.0005707853,0.0004127537,0.000002891679,0.9845373,0.00004791895,0.00001821528,0.0001694914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989375,0.0003011466,0.0002175683,0.00004193836,0.0002127296,0.000186986,0.00004374675,0.000004667971,0.00005370275],"genre_scores_gemma":[0.9981427,0.00009174582,0.001367202,0.00008747879,0.0002096202,0.00001801078,0.0000114797,0.00003560009,0.00003616858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003745567,"threshold_uncertainty_score":0.7257808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01663114874672492,"score_gpt":0.2993458072162923,"score_spread":0.2827146584695674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}