{"id":"W2147383407","doi":"10.1158/1078-0432.ccr-06-2974","title":"Akt/cAMP-Responsive Element Binding Protein/Cyclin D1 Network: A Novel Target for Prostate Cancer Inhibition in Transgenic Adenocarcinoma of Mouse Prostate Model Mediated by Nexrutine, a <i>Phellodendron Amurense</i> Bark Extract","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; U.S. Public Health Service; National Institutes of Health; Thomas Jefferson University","keywords":"Tramp; CREB; Prostate cancer; Protein kinase B; Cyclin D1; Cancer research; Prostate; PI3K/AKT/mTOR pathway; LNCaP; Cancer; Phosphorylation; Genetically modified mouse; Medicine; Transgene; Signal transduction; Endocrinology; Internal medicine; Biology; Cell cycle; Cell biology; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007940875,0.0003589031,0.0002984617,0.0002796793,0.0001497497,0.0001617972,0.0002044812,0.0001922638,0.001286806],"category_scores_gemma":[0.00003579126,0.000124293,0.0002565667,0.0001441998,0.0001982988,0.000207762,0.0001224193,0.0005669505,0.0001801991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271392,"about_ca_system_score_gemma":0.0002074305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004037286,"about_ca_topic_score_gemma":0.0008899795,"domain_scores_codex":[0.9999505,0.00000541475,0.000002879284,0.00001410467,0.00001365634,0.00001343851],"domain_scores_gemma":[0.9999737,0.000001677388,0.0000110437,0.000002156189,0.000002488263,0.000008959264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002497594,0.00007074222,0.0001323664,0.00007165151,0.000006728369,0.00003947451,0.000008515984,0.0000632276,0.9977568,0.00007745086,0.00005453309,0.00146876],"study_design_scores_gemma":[0.0001146325,0.001110565,0.005120662,0.00001450355,0.00005392291,0.0003430432,0.00003636948,0.001484309,0.9880078,0.0001024998,0.003605422,0.000006262129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895697,0.002862775,0.004648789,0.0002623645,0.00005376134,0.00007438596,0.0004925019,0.0002491135,0.001786612],"genre_scores_gemma":[0.9912397,0.002007837,0.003396288,0.00007837267,0.00001049587,0.0001144674,0.0005673061,0.00001770972,0.002567768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286806,"threshold_uncertainty_score":0.004304767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0986099828606956,"score_gpt":0.4183267336956671,"score_spread":0.3197167508349715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}