{"id":"W2147383407","doi":"10.1158/1078-0432.ccr-06-2974","title":"Akt/cAMP-Responsive Element Binding Protein/Cyclin D1 Network: A Novel Target for Prostate Cancer Inhibition in Transgenic Adenocarcinoma of Mouse Prostate Model Mediated by Nexrutine, a <i>Phellodendron Amurense</i> Bark Extract","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; U.S. Public Health Service; National Institutes of Health; Thomas Jefferson University","keywords":"Tramp; CREB; Prostate cancer; Protein kinase B; Cyclin D1; Cancer research; Prostate; PI3K/AKT/mTOR pathway; LNCaP; Cancer; Phosphorylation; Genetically modified mouse; Medicine; Transgene; Signal transduction; Endocrinology; Internal medicine; Biology; Cell cycle; Cell biology; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.006677866,0.0003099559,0.0005841093,0.0001145486,0.0001496111,0.0000308731,0.0002654298,0.0005096734,0.00006077474],"category_scores_gemma":[0.001004903,0.0002523408,0.0002760869,0.0004521216,0.0004320687,0.00001816243,0.0001688364,0.0006965139,0.000002607517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001493528,"about_ca_system_score_gemma":0.000595057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003309119,"about_ca_topic_score_gemma":0.001124953,"domain_scores_codex":[0.9955333,0.0004687212,0.001226605,0.001017902,0.0005293529,0.001224109],"domain_scores_gemma":[0.997929,0.0006111898,0.0003350217,0.0003564604,0.0004851115,0.0002831639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01097863,0.0008120603,0.01543724,0.0001166745,0.00008394061,0.00000427763,0.00004184216,0.0008551281,0.964282,0.000008315356,0.002538524,0.004841345],"study_design_scores_gemma":[0.003882139,0.002066846,0.003392453,0.0002017931,0.00002425326,0.00000132006,0.00007704701,0.002719084,0.9830555,0.0001329197,0.004032614,0.0004140687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904343,0.002004586,0.002055102,0.0006931979,0.00009018143,0.00299092,0.001688011,0.00001530916,0.00002836986],"genre_scores_gemma":[0.9940127,0.001497258,0.001154783,0.0001588147,0.0003070188,0.001341918,0.0004038344,0.00005304994,0.001070583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01877344,"threshold_uncertainty_score":0.9999929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0986099828606956,"score_gpt":0.4183267336956671,"score_spread":0.3197167508349715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}