{"id":"W2147409322","doi":"10.1074/jbc.m109.027235","title":"Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; University of Oxford; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Geranylgeranyl pyrophosphate; Asparagine; Biochemistry; Farnesyl pyrophosphate; Plasmodium falciparum; Pyrophosphate; Biology; Biosynthesis; ATP synthase; Yeast; Stereochemistry; Protein subunit; Structural motif; Enzyme; Residue (chemistry); Chemistry; Prenylation; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000558085,0.000275636,0.0001564766,0.0001196897,0.00009236448,0.000139351,0.0001228212,0.0001625094,0.000620049],"category_scores_gemma":[0.0001411871,0.00007584912,0.000135828,0.0001123132,0.0001115319,0.0001792623,0.0001144479,0.0002700713,0.0003719483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001013811,"about_ca_system_score_gemma":0.0001170044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004983142,"about_ca_topic_score_gemma":0.0004253683,"domain_scores_codex":[0.9999657,0.000005167811,0.000003151938,0.000008648522,0.00001105157,0.000006344294],"domain_scores_gemma":[0.9999213,0.00001850787,0.00001713308,0.000007523808,0.00001237871,0.00002312489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004564215,0.00001165646,0.0002791421,0.00003780982,0.000003169136,0.0001493829,0.0000191508,0.00007223108,0.9983246,0.00004741848,0.00001870464,0.0009909886],"study_design_scores_gemma":[0.00003613961,0.0008208363,0.02946234,0.0000124018,0.00004048378,0.004799433,0.0001500318,0.00220081,0.9458296,0.0002413273,0.01639063,0.00001585891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921267,0.001243285,0.004715833,0.0001173923,0.00001416914,0.00004376551,0.0008140268,0.00003785062,0.0008869179],"genre_scores_gemma":[0.9802265,0.001372306,0.01063237,0.00004565759,0.00001614203,0.00002616075,0.005077562,0.00002623255,0.002577086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000620049,"threshold_uncertainty_score":0.002074242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412736122596332,"score_gpt":0.2598150030463878,"score_spread":0.2456876418204245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}