{"id":"W2147409322","doi":"10.1074/jbc.m109.027235","title":"Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; University of Oxford; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Geranylgeranyl pyrophosphate; Asparagine; Biochemistry; Farnesyl pyrophosphate; Plasmodium falciparum; Pyrophosphate; Biology; Biosynthesis; ATP synthase; Yeast; Stereochemistry; Protein subunit; Structural motif; Enzyme; Residue (chemistry); Chemistry; Prenylation; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002244764,0.0001957306,0.000321566,0.00002391488,0.00003298962,0.00002179473,0.000423644,0.000475913,0.0001426772],"category_scores_gemma":[0.0004254977,0.0001465393,0.0002731686,0.00009781965,0.0002434209,0.00000602125,0.0001317248,0.0004406715,0.00000203305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007314639,"about_ca_system_score_gemma":0.00009079416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004936546,"about_ca_topic_score_gemma":2.896513e-7,"domain_scores_codex":[0.9986864,0.00002854314,0.0005050768,0.0002792317,0.000253829,0.0002468578],"domain_scores_gemma":[0.9987938,0.00003137581,0.0003786946,0.0002857183,0.0003014,0.0002090099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004416161,0.0003504156,0.001308434,0.0000233297,0.00009276369,0.00002775635,0.000006036997,0.000003927751,0.9970866,0.000007836103,0.00003391879,0.0006173085],"study_design_scores_gemma":[0.0009037644,0.0001928033,0.001972363,0.00002681127,0.00002140508,0.00006904563,0.000007014313,0.00003921436,0.9942334,0.00004706648,0.002315009,0.0001720873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963893,0.0003334465,0.002650851,0.0001723817,0.0001149437,0.00007513491,0.0001121517,0.000005387767,0.0001463793],"genre_scores_gemma":[0.9977192,0.0001722951,0.001399037,0.0001282545,0.000312803,0.000004512541,0.0002113519,0.00001614257,0.00003637681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002853241,"threshold_uncertainty_score":0.5975701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412736122596332,"score_gpt":0.2598150030463878,"score_spread":0.2456876418204245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}