{"id":"W2147415910","doi":"10.1002/cmdc.200700094","title":"Naphthyl Tetronic Acids as Multi‐Target Inhibitors of Bacterial Peptidoglycan Biosynthesis","year":2007,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Peptidoglycan; Biosynthesis; Chemistry; Biochemistry; Enzyme; Peptide; Stereochemistry; IC50; Escherichia coli; Combinatorial chemistry; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164548,0.0004345234,0.0003744747,0.0004220926,0.0001385431,0.0002681002,0.0003126763,0.0002509409,0.001423605],"category_scores_gemma":[0.0001153689,0.0002224732,0.0001627392,0.000291981,0.0001463498,0.0001960772,0.0002313326,0.000537695,0.0003704232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004569817,"about_ca_system_score_gemma":0.0002430548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001283582,"about_ca_topic_score_gemma":0.004553066,"domain_scores_codex":[0.9998915,0.00002141651,0.000008567327,0.0000158666,0.00003230413,0.00003035574],"domain_scores_gemma":[0.9999341,0.0000125143,0.00001291868,0.000005529444,0.00000958358,0.0000254558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003847951,0.0001673358,0.0001909477,0.0001061781,0.00002469447,0.0001602658,0.00003245401,0.001442402,0.9850141,0.0003192934,0.0003152087,0.01184236],"study_design_scores_gemma":[0.0002266661,0.002777739,0.002498122,0.00002263439,0.00005299996,0.0004181152,0.00002528753,0.002996269,0.9832562,0.0001175619,0.007587518,0.00002086529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810405,0.007973563,0.003638854,0.0002074736,0.00006373008,0.0002035558,0.0008431101,0.0002368937,0.005792214],"genre_scores_gemma":[0.981999,0.00645966,0.004508365,0.00008811719,0.00002007354,0.00008007491,0.001195969,0.00002960275,0.005619057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001423605,"threshold_uncertainty_score":0.004762411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008021629784548444,"score_gpt":0.2357026424017273,"score_spread":0.2276810126171789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}