{"id":"W2147431060","doi":"10.1261/rna.2475211","title":"Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery","year":2011,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Start codon; Biology; Eukaryotic translation; Eukaryotic initiation factor; Translation (biology); Genetics; Open reading frame; Initiation factor; Silent mutation; Translational regulation; Computational biology; Stop codon; Eukaryotic translation initiation factor 4 gamma; EIF4A1; eIF2; Cell biology; Mutation; Gene; Messenger RNA; Peptide sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004597875,0.0000633762,0.00007002924,0.00001083608,0.00005687257,0.000005322322,0.000152813,0.00005355842,0.0000796356],"category_scores_gemma":[0.00005123502,0.00003975518,0.00006784932,0.0000352493,0.00008000272,0.000004261331,0.00001424888,0.00003183495,0.000002574621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002339318,"about_ca_system_score_gemma":0.00002716474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008637679,"about_ca_topic_score_gemma":0.00002223196,"domain_scores_codex":[0.9993619,0.0001365957,0.0002024113,0.0001102121,0.0001228163,0.00006601537],"domain_scores_gemma":[0.999492,0.00002825084,0.0001561489,0.0002360062,0.00006460808,0.00002291309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001146638,0.00005347341,0.001156516,0.00001327663,0.00003019509,8.039275e-8,0.0001010675,0.000001697399,0.9907774,0.00009194989,0.0005252384,0.007134422],"study_design_scores_gemma":[0.0001110325,0.0000509727,0.009637753,0.000009015569,0.00003105212,0.000002743884,0.00004794263,0.00005883477,0.9867157,0.003035635,0.0002490119,0.00005030413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897329,0.0005193378,0.008358419,0.0001686319,0.00006398576,0.0001993081,0.0000959667,0.000003365929,0.0008580721],"genre_scores_gemma":[0.9993383,0.00007728975,0.0002187632,0.00008042986,0.00002668412,0.00001494699,0.0001486133,0.000006654473,0.00008827901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009605427,"threshold_uncertainty_score":0.1621169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03613499119406015,"score_gpt":0.2404568756347361,"score_spread":0.2043218844406759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}