{"id":"W2147446676","doi":"10.1128/iai.01546-08","title":"Restriction of <i>L</i> <i>egionella pneumophila</i> Replication in Macrophages Requires Concerted Action of the Transcriptional Regulators Irf1 and Irf8 and Nod-Like Receptors Naip5 and Nlrc4","year":2009,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Legionella pneumophila; Biology; NLRC4; Microbiology; IRF1; Permissiveness; Cell biology; Inflammasome; Virology; Receptor; Viral replication; Gene; Genetics; Transcription factor; Virus; Caspase 1; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002580253,0.00009445777,0.0001192554,0.00007361307,0.0001405192,0.00001531617,0.0000395578,0.0001303532,0.000001639649],"category_scores_gemma":[0.00006541726,0.00007854108,0.00002813398,0.0001762492,0.0002676721,0.00002337477,0.00003620368,0.0001341318,5.136067e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001199354,"about_ca_system_score_gemma":0.0000256105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000537939,"about_ca_topic_score_gemma":0.00007570445,"domain_scores_codex":[0.9992302,0.0001583147,0.000211194,0.0002112227,0.00009549325,0.00009355121],"domain_scores_gemma":[0.9995452,0.00002201333,0.0001116391,0.0002063383,0.00007676571,0.00003805713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001525312,0.00005797164,0.04001875,0.00003919536,0.00001153891,1.064473e-7,0.0001247181,0.0000051855,0.9501177,0.0001406676,0.0001194708,0.009212143],"study_design_scores_gemma":[0.000770923,0.0003358597,0.7350416,0.00004336847,0.00001476928,0.00003546537,0.0001166188,0.00007469827,0.2603558,0.0003451509,0.002771757,0.00009399305],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981478,0.0009578827,0.00003672673,0.0004145369,0.0001022775,0.0001781988,0.00000540033,0.000006048182,0.0001510829],"genre_scores_gemma":[0.9902995,0.009467542,0.00001444504,0.00008498361,0.00002951478,0.00000503008,0.00001997227,0.000005321766,0.00007367436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6950228,"threshold_uncertainty_score":0.3202812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01937891545467945,"score_gpt":0.2797223527596952,"score_spread":0.2603434373050157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}