{"id":"W2147446676","doi":"10.1128/iai.01546-08","title":"Restriction of <i>L</i> <i>egionella pneumophila</i> Replication in Macrophages Requires Concerted Action of the Transcriptional Regulators Irf1 and Irf8 and Nod-Like Receptors Naip5 and Nlrc4","year":2009,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McGill University","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Legionella pneumophila; Biology; NLRC4; Microbiology; IRF1; Permissiveness; Cell biology; Inflammasome; Virology; Receptor; Viral replication; Gene; Genetics; Transcription factor; Virus; Caspase 1; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407911,0.0003314268,0.0001855174,0.0001431549,0.0001384695,0.0002903291,0.0001899078,0.0002550748,0.0009337937],"category_scores_gemma":[0.00008539982,0.000164669,0.0003000603,0.00006935755,0.0002053751,0.0001327509,0.000230632,0.0004569782,0.0004928368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261088,"about_ca_system_score_gemma":0.0001598188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005125986,"about_ca_topic_score_gemma":0.0007780656,"domain_scores_codex":[0.9997738,0.00003250076,0.00002761879,0.00004677094,0.00004472842,0.00007460586],"domain_scores_gemma":[0.9998331,0.00001737867,0.00007041965,0.00002511853,0.00001402022,0.00003988623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004596224,0.000007943308,0.0001683551,0.000006647359,0.000001031974,0.00001870752,0.000004129633,0.000007737621,0.999603,0.00001636565,0.00001020705,0.0001099339],"study_design_scores_gemma":[0.00001126873,0.0001697252,0.007752128,0.000005289613,0.00000976902,0.0002932619,0.00003452816,0.000370653,0.9906746,0.00003041986,0.0006445445,0.000003916452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974849,0.0003005927,0.001014325,0.00008535235,0.00001217165,0.00001124142,0.0002650623,0.00007259804,0.0007537345],"genre_scores_gemma":[0.9967,0.0001558858,0.001161646,0.00006415141,0.000007620134,0.00002411912,0.0005076975,0.00002293846,0.00135587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009337937,"threshold_uncertainty_score":0.003123879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01937891545467945,"score_gpt":0.2797223527596952,"score_spread":0.2603434373050157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}