{"id":"W2147531105","doi":"10.1038/nsmb1316","title":"p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation","year":2007,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Stem Cell Network","funders":"National Institutes of Health","keywords":"Biology; H3K4me3; Histone methyltransferase; Methyltransferase; Epigenetics; Cell biology; Histone; Regulation of gene expression; Gene; Psychological repression; Signal transduction; Histone H3; Cellular differentiation; PRC2; Genetics; Promoter; Gene expression; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003219402,0.0002915392,0.0003256609,0.0001801147,0.0001169473,0.00001962543,0.000243978,0.0005404938,0.00002265411],"category_scores_gemma":[0.00008707469,0.0002641672,0.000175396,0.0001965991,0.00007887981,0.000004781493,0.000103908,0.0002433783,0.000001320231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003187338,"about_ca_system_score_gemma":0.00002096104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001704156,"about_ca_topic_score_gemma":0.00003043057,"domain_scores_codex":[0.9981911,0.0001462987,0.0005004301,0.0005702329,0.0001708239,0.0004210997],"domain_scores_gemma":[0.9990506,0.00003159541,0.0002123832,0.0003720167,0.0002051367,0.0001282482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003000215,0.00001120675,0.002924277,0.00002302022,0.0001117475,0.000005807238,0.00007446613,0.0003656208,0.9871656,0.001778315,0.000002283753,0.00723758],"study_design_scores_gemma":[0.0005400406,0.0003909397,0.03447174,0.0000172159,0.00003306934,0.000007133835,0.00004952545,0.00001363731,0.9620649,0.001249343,0.000880175,0.0002822946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575768,0.009665946,0.03167872,0.00009879427,0.0003637218,0.0004999132,0.00003663633,0.00001818179,0.00006129382],"genre_scores_gemma":[0.9891272,0.000118108,0.00981817,0.0001144913,0.0002454305,0.00001282779,0.0005105638,0.00003442791,0.00001881882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03155037,"threshold_uncertainty_score":0.999981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497586476372714,"score_gpt":0.3197967564254984,"score_spread":0.3048208916617712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}