{"id":"W2147532728","doi":"10.1128/ec.00222-08","title":"The Synthetic Genetic Network around <i>PKC1</i> Identifies Novel Modulators and Components of Protein Kinase C Signaling in <i>Saccharomyces cerevisiae</i>","year":2008,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council","keywords":"Mutant; Saccharomyces cerevisiae; Biology; Genetics; GTPase; Gene; Signal transduction; Epistasis; Genetic screen; Protein kinase C; Cell biology; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008420287,0.0004994893,0.0001827985,0.0003866367,0.0001837625,0.000317117,0.0002393151,0.0001811288,0.001131291],"category_scores_gemma":[0.00009011276,0.0001848494,0.0002553297,0.0002491111,0.0002164421,0.0001017273,0.000269646,0.0004503924,0.0003206255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006626261,"about_ca_system_score_gemma":0.0003559418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001908042,"about_ca_topic_score_gemma":0.004048737,"domain_scores_codex":[0.9998749,0.00001111908,0.00001330531,0.00003504425,0.00004391369,0.00002168841],"domain_scores_gemma":[0.9998549,0.00002184282,0.00005494025,0.00001500072,0.00001302703,0.00004027964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000556485,0.00001591919,0.0004116744,0.00001173035,0.000003305841,0.00003703548,0.000004716694,0.0001096241,0.9984086,0.00009243443,0.00002014529,0.0008290625],"study_design_scores_gemma":[0.00001651105,0.0001494729,0.01122509,0.000007059342,0.00004378038,0.0004201921,0.00003415002,0.002431328,0.9823663,0.00007807399,0.003220096,0.000007805214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929366,0.0002913964,0.004463154,0.00008982357,0.00001571768,0.00003880563,0.0008105224,0.0001489961,0.001204984],"genre_scores_gemma":[0.9876177,0.0003748968,0.007412962,0.00008058654,0.000006423586,0.00003659716,0.001951128,0.00006272675,0.002457013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001908042,"threshold_uncertainty_score":0.004807711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522374841697622,"score_gpt":0.2199839088657569,"score_spread":0.2047601604487806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}