{"id":"W2147533489","doi":"10.1074/jbc.m110.191452","title":"Kaposi Sarcoma-associated Herpesvirus Degrades Cellular Toll-Interleukin-1 Receptor Domain-containing Adaptor-inducing β-Interferon (TRIF)","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Center for Research Resources; National Cancer Institute","keywords":"TRIF; Signal transducing adaptor protein; Ubiquitin ligase; Cell biology; Innate immune system; Biology; Ubiquitin; Lytic cycle; Interferon; Signal transduction; Toll-like receptor; Virology; Receptor; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760616,0.0004227537,0.0002300717,0.0001874155,0.00009882585,0.0002003368,0.0001113457,0.0001759245,0.0008762501],"category_scores_gemma":[0.0001141388,0.0001115649,0.0003419858,0.00008869458,0.0001009448,0.0001757952,0.0001656762,0.0003528533,0.0003924243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001493528,"about_ca_system_score_gemma":0.0001440449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000198769,"about_ca_topic_score_gemma":0.0001815896,"domain_scores_codex":[0.9998538,0.00002326174,0.00001992175,0.00003116965,0.00003442472,0.00003732426],"domain_scores_gemma":[0.9999031,0.00001033269,0.00003886849,0.00001263161,0.00001421793,0.00002095517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008338007,0.00001690089,0.0001580406,0.00006585981,0.000007395886,0.00003114016,0.000006578564,0.00003585752,0.9974437,0.00005357082,0.00004467634,0.002052971],"study_design_scores_gemma":[0.00001613194,0.0003573662,0.005995052,0.000008900114,0.00002026997,0.0005915584,0.00001624289,0.0004603321,0.9889376,0.00004323192,0.003547205,0.000006105413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972505,0.01359512,0.008828201,0.0001088838,0.0001014747,0.00006963381,0.0008867492,0.0003329027,0.003572105],"genre_scores_gemma":[0.9906879,0.0033486,0.002787475,0.00006690937,0.00001863955,0.00004597759,0.0008258357,0.00001698073,0.002201661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008762501,"threshold_uncertainty_score":0.002931356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0457786660619964,"score_gpt":0.2576083199590283,"score_spread":0.2118296538970319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}