{"id":"W2147568004","doi":"10.1002/prot.10108","title":"Anti‐cooperativity and cooperativity in hydrophobic interactions: Three‐body free energy landscapes and comparison with implicit‐solvent potential functions for proteins","year":2002,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cooperativity; Chemistry; Solvent models; Potential of mean force; Molecular dynamics; Energy landscape; Thermodynamics; Hydrophobic effect; Chemical physics; Solvent; Accessible surface area; Computational chemistry; Statistical physics; Physics; Organic chemistry; Solvation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008778721,0.0003181151,0.0003251554,0.0001246321,0.0003550727,0.0001535789,0.00008435144,0.0002067886,0.000021021],"category_scores_gemma":[0.00004157293,0.0002376012,0.00004043933,0.0001538163,0.0001295919,0.00006966889,0.0001310655,0.0002121663,3.942839e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001843841,"about_ca_system_score_gemma":0.00003094799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007105809,"about_ca_topic_score_gemma":0.003064275,"domain_scores_codex":[0.9988303,0.00003741415,0.0003651063,0.0003485623,0.0001397789,0.0002788743],"domain_scores_gemma":[0.9993017,0.00001498989,0.0001669448,0.000288407,0.0001134536,0.00011454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002459095,0.0005565131,0.03869991,0.001172594,0.0006685333,0.000006873059,0.000927457,0.002550792,0.8431926,0.003271202,0.001590155,0.1049043],"study_design_scores_gemma":[0.01672406,0.009729192,0.06245968,0.0003315004,0.0004886184,0.001071589,0.001198862,0.8015856,0.07080803,0.003642729,0.02915913,0.002801015],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7684776,0.0007186137,0.2289329,0.0002356598,0.0001336895,0.001163303,0.000197898,0.00002991475,0.0001103875],"genre_scores_gemma":[0.990828,0.0001603007,0.008221679,0.0001582971,0.0001467704,0.0001574467,0.0002131464,0.00002119059,0.00009317795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7990348,"threshold_uncertainty_score":0.9689097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006329224673341593,"score_gpt":0.2121875734988365,"score_spread":0.2058583488254949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}