{"id":"W2147593372","doi":"10.1038/ng.946","title":"Identification of genetic elements that autonomously determine DNA methylation states","year":2011,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":398,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; University of British Columbia","keywords":"Biology; DNA methylation; RNA-Directed DNA Methylation; Epigenetics; Methylation; Epigenetics of physical exercise; Genetics; CpG site; Epigenomics; Illumina Methylation Assay; DNA; Molecular biology; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002869706,0.0002216553,0.0002448311,0.0004247911,0.0002413559,0.0006144089,0.0004727602,0.0004955067,0.001384254],"category_scores_gemma":[0.0006104547,0.0003536398,0.000242475,0.0001451014,0.0004278407,0.0004026529,0.0005879729,0.0009576387,0.0006798545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004181951,"about_ca_system_score_gemma":0.0003031401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008461826,"about_ca_topic_score_gemma":0.002034582,"domain_scores_codex":[0.9998319,0.00001593492,0.000009915746,0.00006051524,0.00005443087,0.00002727987],"domain_scores_gemma":[0.9995442,0.0001961762,0.0000716871,0.00008394575,0.000038339,0.00006553982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005172945,0.00001341987,0.0003409828,0.000009292676,0.000001994608,0.00002308549,0.00001586121,0.00006827481,0.9960698,0.001073355,0.00003146686,0.002300708],"study_design_scores_gemma":[0.00001205873,0.00003863447,0.003697064,0.000002874334,0.000008595018,0.0001222885,0.0000215482,0.002234951,0.9910716,0.0006782207,0.002103315,0.000008737249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502488,0.000885983,0.0407662,0.0003665025,0.0001208297,0.00005064228,0.0006245868,0.0004790631,0.006457381],"genre_scores_gemma":[0.9804556,0.000293403,0.01323229,0.0001096874,0.00001812682,0.00002811325,0.0006506104,0.0001281133,0.005084051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384254,"threshold_uncertainty_score":0.004630804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01686941295586851,"score_gpt":0.2711247217578682,"score_spread":0.2542553088019996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}