{"id":"W2147615363","doi":"10.1093/hmg/dds334","title":"Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls","year":2012,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":240,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"FP7 Research Potential of Convergence Regions; National Cancer Institute; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National High-tech Research and Development Program; European Regional Development Fund; University of Texas MD Anderson Cancer Center; U.S. Public Health Service; National Institutes of Health; Synchrotron Light Research Institute; Institut National Du Cancer; Tartu Ülikool; Canadian Cancer Society Research Institute; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; Cancer Care Ontario; Cancer Prevention and Research Institute of Texas; Norges Forskningsråd; Wellcome Trust; Cancer Research UK; Henry Ford Health System; American Cancer Society; Georgetown University; University of Colorado Denver; Deutsche Krebshilfe; National Natural Science Foundation of China; University of Pittsburgh; Johns Hopkins University; Bundesamt für Strahlenschutz; Sanofi; Roy Castle Lung Cancer Foundation; University of California, Los Angeles; University of Minnesota","keywords":"Biology; Lung cancer; CDKN2A; Genome-wide association study; Lung cancer susceptibility; Genetics; p14arf; Genetic association; Cancer; Oncology; Carcinogenesis; Single-nucleotide polymorphism; Gene; Genotype; Medicine; Tumor suppressor gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009005791,0.002099285,0.006410736,0.002030364,0.0008405253,0.002265155,0.00140652,0.0015993,0.002081007],"category_scores_gemma":[0.01324458,0.001343096,0.01930217,0.00356331,0.0005660313,0.0007554945,0.001130802,0.001556077,0.0003281241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008917489,"about_ca_system_score_gemma":0.0008108091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008024647,"about_ca_topic_score_gemma":0.009588482,"domain_scores_codex":[0.9919714,0.003481512,0.001302515,0.002212231,0.0007487749,0.0002835098],"domain_scores_gemma":[0.9939783,0.003582244,0.0006767423,0.001085667,0.0004552582,0.0002218522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.01048405,0.00005224833,0.1401453,0.003093703,0.8355585,0.0004503203,0.00008540094,0.00124847,0.001502965,0.0001508934,0.0009608889,0.006267205],"study_design_scores_gemma":[0.00177259,0.0006050344,0.09267384,0.0003478944,0.8990715,0.0004948048,0.00007352534,0.002042956,0.0006050378,0.0006580918,0.001619926,0.00003493381],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5412319,0.4364672,0.01213834,0.001012094,0.001154167,0.0003087626,0.005365208,0.000511298,0.00181102],"genre_scores_gemma":[0.9816461,0.01325913,0.002288225,0.0003711118,0.0001623652,0.000149492,0.001560046,0.00008769434,0.0004759638],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.009005791,"threshold_uncertainty_score":0.04762769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05988792514081067,"score_gpt":0.3635077928648137,"score_spread":0.3036198677240031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}