{"id":"W2147619880","doi":"10.1158/1078-0432.ccr-10-1382","title":"Tumor Growth Inhibition by Olaparib in <i>BRCA2</i> Germline-Mutated Patient-Derived Ovarian Cancer Tissue Xenografts","year":2010,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Olaparib; PARP inhibitor; Ovarian cancer; Synthetic lethality; Cancer research; Carboplatin; BRCA mutation; Medicine; Cancer; Serous fluid; Serous carcinoma; In vivo; DNA repair; Biology; Internal medicine; Poly ADP ribose polymerase; Chemotherapy; Cisplatin; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001665956,0.0003094513,0.0002807667,0.0001702229,0.0001082965,0.0002197645,0.0001875179,0.0001805899,0.000905324],"category_scores_gemma":[0.0001373168,0.00009113864,0.0001856845,0.0001613978,0.0001139379,0.0001569315,0.0001091542,0.0005008149,0.0002620331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111809,"about_ca_system_score_gemma":0.0001905768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003894934,"about_ca_topic_score_gemma":0.0004744242,"domain_scores_codex":[0.9999086,0.00002541969,0.00001128969,0.00001696818,0.00002165111,0.00001603701],"domain_scores_gemma":[0.9998842,0.00004021238,0.00002150639,0.00002096499,0.000009437015,0.00002370123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005777418,0.0003164051,0.001032115,0.00006478484,0.00001194653,0.000172239,0.0000282409,0.0004092103,0.9936893,0.0001016499,0.0001899371,0.003406361],"study_design_scores_gemma":[0.0001593597,0.00346972,0.00905593,0.000009256448,0.00003391213,0.001915454,0.00003276098,0.003053195,0.9787829,0.00004765918,0.003434029,0.000005774639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962191,0.0009262692,0.001154058,0.00005847049,0.00001732893,0.00004720557,0.0005062306,0.00007262072,0.0009987246],"genre_scores_gemma":[0.9958019,0.0006276257,0.001762013,0.0000307098,0.000006803634,0.00005250209,0.001008486,0.00002004425,0.0006898905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000905324,"threshold_uncertainty_score":0.003028631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1016430998596772,"score_gpt":0.4953177757048305,"score_spread":0.3936746758451533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}