{"id":"W2147621051","doi":"10.1158/1078-0432.ccr-11-2181","title":"Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada); Institute of Cancer Research","funders":"National Cancer Institute; Cancer Research UK","keywords":"Oncolytic virus; Carboplatin; Paclitaxel; Medicine; Chemotherapy; Oncology; Internal medicine; Cancer; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002561504,0.0001410162,0.0003330733,0.0001650918,0.0000604114,0.00001174948,0.0001879426,0.0001655217,0.00002180211],"category_scores_gemma":[0.0002862718,0.0001103683,0.00003285864,0.0004271393,0.0004887696,0.00001608391,0.00009342459,0.0004252294,8.847257e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009489769,"about_ca_system_score_gemma":0.0004364425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001777438,"about_ca_topic_score_gemma":0.001160109,"domain_scores_codex":[0.9975453,0.0005206782,0.0004560756,0.0003753228,0.0005574445,0.0005452024],"domain_scores_gemma":[0.9989316,0.0001656344,0.0001081226,0.0003553914,0.0002822317,0.0001570026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6164546,0.01056576,0.1448673,0.0000767533,0.00007771134,0.000004174646,0.0004755346,0.00002594161,0.03025462,0.00002934604,0.00005126907,0.197117],"study_design_scores_gemma":[0.4428487,0.2747777,0.1897966,0.0002732095,0.00001369134,9.5322e-7,0.0002472165,0.00005403422,0.09015098,0.0001000676,0.001277627,0.0004591637],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974841,0.0008037869,0.000005956623,0.000163288,0.00004653511,0.001350275,0.00002003956,0.000003494716,0.0001224982],"genre_scores_gemma":[0.9985081,0.0008541873,0.0001046912,0.00006228124,0.0001060952,0.0002186852,0.00002863686,0.00003157096,0.00008576425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.264212,"threshold_uncertainty_score":0.4500689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06457057541320321,"score_gpt":0.4478147690360461,"score_spread":0.3832441936228429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}