{"id":"W2147621051","doi":"10.1158/1078-0432.ccr-11-2181","title":"Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada); Institute of Cancer Research","funders":"National Cancer Institute; Cancer Research UK","keywords":"Oncolytic virus; Carboplatin; Paclitaxel; Medicine; Chemotherapy; Oncology; Internal medicine; Cancer; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001110856,0.001656621,0.002367319,0.0004268365,0.0004522559,0.001078666,0.0009698822,0.001271956,0.002936479],"category_scores_gemma":[0.0006955492,0.0005137331,0.001048811,0.0006203232,0.00113129,0.0006392855,0.0003469315,0.003638079,0.0006808391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001080924,"about_ca_system_score_gemma":0.001715674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039661,"about_ca_topic_score_gemma":0.002058954,"domain_scores_codex":[0.9996573,0.0001521023,0.00001823607,0.00006876318,0.00003125901,0.0000724459],"domain_scores_gemma":[0.999403,0.00009418868,0.0001137581,0.00006132951,0.00002552358,0.0003021953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6967216,0.07979519,0.01066061,0.00095745,0.001432103,0.0004515618,0.0004158416,0.004749687,0.0583852,0.0005960087,0.005112881,0.140722],"study_design_scores_gemma":[0.6261614,0.3532859,0.008348415,0.00004647798,0.0003600324,0.0003820956,0.0000595062,0.001885385,0.006075012,0.0002378432,0.003135789,0.00002215883],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894775,0.002712538,0.0007390752,0.0005653354,0.000150217,0.003210188,0.0006256755,0.0001282778,0.002391185],"genre_scores_gemma":[0.9876709,0.001775667,0.00247603,0.000803398,0.0001743243,0.00306372,0.001769458,0.00003471537,0.00223174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002936479,"threshold_uncertainty_score":0.009823501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06457057541320321,"score_gpt":0.4478147690360461,"score_spread":0.3832441936228429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}