{"id":"W2147645628","doi":"10.1021/bi0024254","title":"Active Site of Chondroitin AC Lyase Revealed by the Structure of Enzyme−Oligosaccharide Complexes and Mutagenesis<sup>,</sup>","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Tetrasaccharide; Chemistry; Lyase; Stereochemistry; HEXA; Tetra; Active site; Chondroitin sulfate; Glycosyl; Oligosaccharide; Biochemistry; Enzyme; Glycosaminoglycan; Polysaccharide; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316497,0.0005547707,0.0002885586,0.0001593905,0.000219548,0.0008001667,0.0007504577,0.0004469781,0.0007569091],"category_scores_gemma":[0.0002571594,0.0002768518,0.0003032404,0.0002932126,0.0002249637,0.0002447834,0.0001715534,0.0006564276,0.0003428325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001220524,"about_ca_system_score_gemma":0.0004815285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005368834,"about_ca_topic_score_gemma":0.004650362,"domain_scores_codex":[0.9998789,0.00001289068,0.00000891251,0.00003259172,0.00005105488,0.00001563939],"domain_scores_gemma":[0.9998964,0.00001517432,0.00003434941,0.0000106344,0.00002012911,0.00002333686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002679756,0.0000548256,0.001952604,0.00009079404,0.00003376306,0.0002592361,0.0001192328,0.001443985,0.9916375,0.0005003996,0.0002980326,0.003341469],"study_design_scores_gemma":[0.0001004583,0.000227445,0.02772588,0.00003223156,0.0001156942,0.001089001,0.0001758744,0.03405013,0.9202783,0.0004937289,0.01566458,0.00004663169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995123,0.001022507,0.002598549,0.0001183518,0.00001832123,0.00001273004,0.000206091,0.00006494411,0.0008356077],"genre_scores_gemma":[0.9883383,0.0007449387,0.006217199,0.0001142451,0.000009027014,0.00002256557,0.002833173,0.00005068845,0.0016698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005368834,"threshold_uncertainty_score":0.01067513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007847643346579242,"score_gpt":0.2502460933009107,"score_spread":0.2423984499543315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}