{"id":"W2147670015","doi":"10.1016/j.cub.2010.10.028","title":"An Evolutionarily Conserved Autoinhibitory Molecular Switch in ELMO Proteins Regulates Rac Signaling","year":2010,"lang":"en","type":"article","venue":"Current Biology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Rac GTP-Binding Proteins; Biology; Guanine nucleotide exchange factor; Cell biology; Formins; DOCK; RAC1; Signal transducing adaptor protein; CDC42; GTPase; Signal transduction; Cytoskeleton; Actin cytoskeleton; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000438247,0.0002282604,0.0003377234,0.0002048859,0.0001486958,0.00001375236,0.0002749704,0.0004745039,0.0003284038],"category_scores_gemma":[0.0001160521,0.0002081277,0.0001006111,0.0001669275,0.0003481231,0.000140174,0.0000717177,0.0006458377,0.0001472114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004612349,"about_ca_system_score_gemma":0.0001425951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009559811,"about_ca_topic_score_gemma":0.00005369682,"domain_scores_codex":[0.9981877,0.000396009,0.0004604221,0.0004681527,0.00002850502,0.0004591868],"domain_scores_gemma":[0.999194,0.00008182953,0.0001753926,0.0004148167,0.0001000127,0.00003398066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000724479,0.0002759391,0.01413889,0.00001269226,0.00002829477,0.000001347604,0.00009192113,0.0000185009,0.970453,0.00530018,0.0001332135,0.009473605],"study_design_scores_gemma":[0.001669057,0.0002537443,0.08211535,0.00005592122,0.00002217005,0.00003914823,0.00003822727,0.0002316157,0.890284,0.003305993,0.02161813,0.0003666344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988903,0.007663053,0.0003913029,0.0002085733,0.002203506,0.0004315613,0.0000202106,0.0001014033,0.00007733748],"genre_scores_gemma":[0.9989352,0.00003206802,0.000200374,0.00003457587,0.00008430268,0.00007759689,0.0005654874,0.00001832113,0.0000520989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08016896,"threshold_uncertainty_score":0.84872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01402737331134764,"score_gpt":0.2785770588162813,"score_spread":0.2645496855049337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}