{"id":"W2147670494","doi":"10.18433/j3wk5s","title":"Cost-Effectiveness of UGT1A1*28 Genotyping in Preventing Severe Neutropenia Following FOLFIRI Therapy in Colorectal Cancer.","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Irinotecan; Medicine; FOLFIRI; Genotyping; Neutropenia; Febrile neutropenia; Internal medicine; Colorectal cancer; Oncology; Genotype; Gastroenterology; Chemotherapy; Cancer; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003694099,0.001000771,0.00146599,0.0009432809,0.0002479533,0.001014384,0.0007447047,0.001533268,0.002174537],"category_scores_gemma":[0.01243753,0.0005331463,0.002685399,0.0006165383,0.0005609484,0.0008723219,0.0006462446,0.0007992462,0.00008465203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004082663,"about_ca_system_score_gemma":0.003201766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01118763,"about_ca_topic_score_gemma":0.008656556,"domain_scores_codex":[0.9970062,0.002404901,0.00008390701,0.0001446965,0.0001711014,0.0001891484],"domain_scores_gemma":[0.9938877,0.005068705,0.0006172163,0.00007780858,0.0001559182,0.0001927221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.005849864,0.0003531755,0.01352444,0.001636038,0.002031389,0.0003869944,0.00007490103,0.9404081,0.0007079759,0.002102065,0.0005017282,0.03242341],"study_design_scores_gemma":[0.004592306,0.01186604,0.04260556,0.002308311,0.01356718,0.001192651,0.0003603513,0.9046329,0.002851104,0.01213251,0.0036967,0.0001942626],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582908,0.01830818,0.01357601,0.002001493,0.0000949905,0.0009147282,0.00128994,0.00008885199,0.005435103],"genre_scores_gemma":[0.9974183,0.001023993,0.001105812,0.0001033143,0.000007821044,0.0000626291,0.0001015707,0.000003327455,0.0001732378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01118763,"threshold_uncertainty_score":0.02962196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1347224807881289,"score_gpt":0.4204039024839963,"score_spread":0.2856814216958674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}