{"id":"W2147670494","doi":"10.18433/j3wk5s","title":"Cost-Effectiveness of UGT1A1*28 Genotyping in Preventing Severe Neutropenia Following FOLFIRI Therapy in Colorectal Cancer.","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Irinotecan; Medicine; FOLFIRI; Genotyping; Neutropenia; Febrile neutropenia; Internal medicine; Colorectal cancer; Oncology; Genotype; Gastroenterology; Chemotherapy; Cancer; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002176275,0.0001666319,0.0003189958,0.0001510138,0.00006832965,0.00002279628,0.0004658177,0.00005548009,0.00007602429],"category_scores_gemma":[0.00003465035,0.0001385712,0.0001945239,0.000409402,0.0001360954,0.00004233827,0.00009760619,0.0002533259,5.286886e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007108623,"about_ca_system_score_gemma":0.0003439785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001509532,"about_ca_topic_score_gemma":0.00007322982,"domain_scores_codex":[0.9982134,0.0003048773,0.0005255927,0.0002624259,0.0003017414,0.0003919369],"domain_scores_gemma":[0.9993805,0.00006669136,0.0002707284,0.00006528607,0.00009036151,0.0001264838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001264324,0.0002068857,0.05882634,0.00003032561,0.00007149244,0.00002313994,0.00029679,0.0002967769,0.8814877,0.00005028821,0.000003339979,0.05744265],"study_design_scores_gemma":[0.004043084,0.0004429016,0.01208584,0.0001559815,0.00003595029,0.00003509459,0.0001323611,0.0006521415,0.9787842,0.000196737,0.003252665,0.0001830269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992233,0.00619079,0.0002284557,0.00005721656,0.0005701807,0.0003832273,0.000004161909,0.000002633559,0.0003302866],"genre_scores_gemma":[0.9956183,0.003597889,0.0004608511,0.0001662142,0.0001142768,0.0000231934,7.641371e-7,0.00001366065,0.000004869739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09729657,"threshold_uncertainty_score":0.565077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1347224807881289,"score_gpt":0.4204039024839963,"score_spread":0.2856814216958674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}