{"id":"W2147701170","doi":"10.1002/etc.5620190323","title":"Dose-dependent stimulation of hepatic retinoic acid hydroxylation/oxidation and glucuronidation in brook trout,<i>Salvelinus fontinalis</i>, after exposure to 3,3′,4,4′-tetrachlorobiphenyl","year":2000,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Salvelinus; Glucuronidation; Fontinalis; Trout; Hydroxylation; Stimulation; Chemistry; Retinoic acid; Internal medicine; Endocrinology; Biology; Biochemistry; Fish <Actinopterygii>; Fishery; Microsome; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001339979,0.0001712464,0.000161108,0.00002460218,0.000049288,0.00001236355,0.00007880419,0.0002631629,0.0003447256],"category_scores_gemma":[0.00002264488,0.0001877778,0.00003207022,0.00004264144,0.000126398,0.00001679675,0.00005852519,0.0001115358,0.000005682212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004412881,"about_ca_system_score_gemma":0.00001934216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004257144,"about_ca_topic_score_gemma":0.000006916561,"domain_scores_codex":[0.9989524,0.00004815046,0.0003105169,0.0003950608,0.0001165242,0.0001772775],"domain_scores_gemma":[0.999639,0.0000141237,0.0000861989,0.0001825208,0.000006682155,0.00007149381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003130716,0.0001056604,0.04845469,0.00006251087,0.00001385199,0.000004103991,0.0001449631,0.0004234255,0.9444628,8.33401e-7,0.000009551504,0.006004559],"study_design_scores_gemma":[0.0009296857,0.0002589294,0.08006696,0.00002158074,0.00002464397,0.00002982004,0.00007770251,0.0001289776,0.9178594,0.00005715704,0.0003578316,0.0001872978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976558,0.001512273,0.0001280597,0.00004365268,0.00002297082,0.0001993306,0.00001530937,0.000006965296,0.0004156074],"genre_scores_gemma":[0.997865,0.0004923494,0.0002890547,0.0001045192,0.00007143259,0.00005397549,0.0002114138,0.00001699647,0.0008953199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03161227,"threshold_uncertainty_score":0.7657355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00255801419303735,"score_gpt":0.1935843926640654,"score_spread":0.191026378471028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}