{"id":"W2147774366","doi":"10.1371/journal.pgen.1003500","title":"Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":459,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; British Heart Foundation; U.S. National Library of Medicine; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research; National Institute on Aging; Agency for Healthcare Research and Quality; Economic and Social Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Wellcome Trust; Cancer Research UK; Novo Nordisk Fonden; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of General Medical Sciences; National Human Genome Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism","keywords":"Biology; Sexual dimorphism; Genome-wide association study; Anthropometry; Waist; Genetics; Circumference; Single-nucleotide polymorphism; Waist–hip ratio; Locus (genetics); Genetic association; Body mass index; Zoology; Internal medicine; Genotype; Medicine; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006990962,0.0003765798,0.0006219625,0.0002889653,0.0002372855,0.00006415239,0.0003609103,0.0005311682,0.00005417445],"category_scores_gemma":[0.00308157,0.0003899268,0.0001220773,0.0004470678,0.0001082886,0.00001002362,0.0002264427,0.0001959659,0.00002993034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002246259,"about_ca_system_score_gemma":0.0001171609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000257072,"about_ca_topic_score_gemma":0.000148008,"domain_scores_codex":[0.9969662,0.0002808265,0.0008641051,0.0007246498,0.0003193141,0.0008448837],"domain_scores_gemma":[0.9979582,0.0006628696,0.0004567978,0.0003644629,0.000410119,0.0001474791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001074607,0.0003452444,0.8635553,0.00009375936,0.0007111794,0.000001546486,0.0008855143,0.002228864,0.1167716,0.000006720976,0.01213464,0.003254802],"study_design_scores_gemma":[0.002325699,0.001485871,0.9399088,0.00002396228,0.0002622613,0.00000505182,0.002807408,0.003078736,0.04144065,0.00193061,0.005603609,0.001127364],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910151,0.005042639,0.001231337,0.001041471,0.0001741406,0.001208827,0.0001379382,0.00002624664,0.0001223234],"genre_scores_gemma":[0.986083,0.001470342,0.009336149,0.0008403804,0.0004535766,0.000432912,0.0002860929,0.0000667973,0.001030748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07635344,"threshold_uncertainty_score":0.9998553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05797247461814089,"score_gpt":0.3070084887788968,"score_spread":0.2490360141607559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}