{"id":"W2147774366","doi":"10.1371/journal.pgen.1003500","title":"Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":459,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Research Resources; British Heart Foundation; U.S. National Library of Medicine; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute for Health and Care Research; National Institute on Aging; Agency for Healthcare Research and Quality; Economic and Social Research Council; National Center for Advancing Translational Sciences; Medical Research Council; Wellcome Trust; Cancer Research UK; Novo Nordisk Fonden; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of General Medical Sciences; National Human Genome Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism","keywords":"Biology; Sexual dimorphism; Genome-wide association study; Anthropometry; Waist; Genetics; Circumference; Single-nucleotide polymorphism; Waist–hip ratio; Locus (genetics); Genetic association; Body mass index; Zoology; Internal medicine; Genotype; Medicine; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002163908,0.0004551074,0.001058955,0.00130089,0.0004827294,0.0008267124,0.0004010486,0.0003569817,0.002897747],"category_scores_gemma":[0.003346564,0.0002599194,0.001391096,0.003376154,0.0003810069,0.0002779517,0.0006563941,0.0004699673,0.0003422623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001564944,"about_ca_system_score_gemma":0.0003448612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002879703,"about_ca_topic_score_gemma":0.005998327,"domain_scores_codex":[0.9987701,0.0003674647,0.0001799486,0.0004556858,0.0001321846,0.00009472319],"domain_scores_gemma":[0.9971564,0.001247438,0.0006577316,0.0004783913,0.0002420437,0.0002180439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004720317,0.00002503006,0.9814638,0.0001419829,0.002544058,0.000348048,0.0001005361,0.0001475167,0.005100595,0.0001001469,0.0003156851,0.009240561],"study_design_scores_gemma":[0.00004534253,0.0001452428,0.9951181,0.00002349284,0.001398858,0.0007664881,0.0001336735,0.0002091553,0.0005911799,0.0003108023,0.001248285,0.00000924651],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849304,0.007639406,0.002918369,0.0001794741,0.00003314328,0.00004288961,0.003192025,0.00006694673,0.0009972742],"genre_scores_gemma":[0.9936098,0.00144302,0.00207812,0.000141806,0.00002544738,0.00003869929,0.002336049,0.00001940356,0.0003076487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002897747,"threshold_uncertainty_score":0.01144397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05797247461814089,"score_gpt":0.3070084887788968,"score_spread":0.2490360141607559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}