{"id":"W2147823227","doi":"10.1128/jvi.74.9.3941-3947.2000","title":"Adenovirus Vector-Induced Expression of the C-X-C Chemokine IP-10 Is Mediated through Capsid-Dependent Activation of NF-κB","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Banting Research Foundation","keywords":"Biology; Molecular biology; Adenoviridae; Viral vector; Chemokine; Transduction (biophysics); Transcription (linguistics); Reporter gene; Expression vector; Gene expression; Recombinant DNA; Virology; Immune system; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003553127,0.0005260647,0.0003312856,0.0002845407,0.0001790242,0.0003689799,0.0002640621,0.0002296402,0.002555644],"category_scores_gemma":[0.0001935918,0.0002017451,0.0002878922,0.0002277046,0.000350858,0.0002307697,0.0002385408,0.0008890938,0.0008516289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004980168,"about_ca_system_score_gemma":0.0003465125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007181297,"about_ca_topic_score_gemma":0.0007329237,"domain_scores_codex":[0.999685,0.00005499554,0.00004117978,0.00007153494,0.00008568529,0.00006156307],"domain_scores_gemma":[0.9998241,0.00004796809,0.00004062332,0.00002948287,0.00002496096,0.00003292023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001128184,0.00004079315,0.0001309492,0.00009235674,0.000005178266,0.00002448538,0.00002189629,0.00003590407,0.9980891,0.0002460231,0.0000804673,0.001119943],"study_design_scores_gemma":[0.00004049722,0.0003529667,0.001512139,0.00001436596,0.00001611753,0.0002108016,0.00002189365,0.0007958676,0.9880781,0.00006626509,0.008884203,0.000006794668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531781,0.004132797,0.03295661,0.0001954597,0.000330957,0.0003567745,0.002769175,0.000600226,0.00547978],"genre_scores_gemma":[0.9544538,0.00275619,0.02455821,0.00007876658,0.00003615576,0.0003085083,0.004542212,0.00008095485,0.01318514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002555644,"threshold_uncertainty_score":0.008549452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02050676803696435,"score_gpt":0.2993261785870591,"score_spread":0.2788194105500948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}