{"id":"W2147841770","doi":"10.1086/499369","title":"Efavirenz and CYP2B6 Polymorphism: Implications for Drug Toxicity and Resistance","year":2006,"lang":"en","type":"letter","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; University of British Columbia","funders":"GlaxoSmithKline","keywords":"Medicine; Efavirenz; CYP2B6; Toxicity; Drug resistance; Pharmacology; Drug; Internal medicine; Genetics; Virology; CYP3A4; Biology; Human immunodeficiency virus (HIV); Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001440842,0.0003885985,0.0008549659,0.0001297137,0.000262628,0.00006864024,0.00007229625,0.0004362885,0.00002743383],"category_scores_gemma":[0.0003345056,0.0003307668,0.0003083323,0.0001208316,0.0004012969,0.00005972887,0.00007029762,0.0005183115,0.0000184064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009380469,"about_ca_system_score_gemma":0.0002261536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001431791,"about_ca_topic_score_gemma":0.0000826271,"domain_scores_codex":[0.9979286,0.00009200389,0.0006867275,0.0007783745,0.0001517465,0.0003625421],"domain_scores_gemma":[0.9974946,0.001411402,0.000243666,0.0004431397,0.0001307027,0.0002764331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002859617,0.0003881243,0.2815628,0.0002632719,0.0002176927,0.00003733334,0.000008173906,1.771779e-8,0.00000110351,0.0001032251,0.7160745,0.001315159],"study_design_scores_gemma":[0.002825624,0.0001154864,0.3895503,0.0002234985,0.001466292,0.00001287191,0.00000258944,0.000001964307,0.000004689592,0.006191725,0.5992483,0.0003566736],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1016197,0.007406239,0.0001638518,0.8832257,0.0004287956,0.002312341,0.001473359,0.0003812256,0.002988736],"genre_scores_gemma":[0.1514405,0.003243831,0.001186756,0.625642,0.009415844,0.002234097,0.007588942,0.0003214832,0.1989265],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2575837,"threshold_uncertainty_score":0.9999145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0285923259317923,"score_gpt":0.3370671022515641,"score_spread":0.3084747763197718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}