{"id":"W2147841770","doi":"10.1086/499369","title":"Efavirenz and CYP2B6 Polymorphism: Implications for Drug Toxicity and Resistance","year":2006,"lang":"en","type":"letter","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; University of British Columbia","funders":"GlaxoSmithKline","keywords":"Medicine; Efavirenz; CYP2B6; Toxicity; Drug resistance; Pharmacology; Drug; Internal medicine; Genetics; Virology; CYP3A4; Biology; Human immunodeficiency virus (HIV); Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009269243,0.0005231054,0.001341942,0.0004251477,0.001122685,0.001492031,0.0007153385,0.02073812,0.006187933],"category_scores_gemma":[0.009818024,0.0003480062,0.00086278,0.0006766462,0.001188458,0.001480259,0.0004413007,0.01035994,0.00179845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001682499,"about_ca_system_score_gemma":0.0007099271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001353478,"about_ca_topic_score_gemma":0.002338276,"domain_scores_codex":[0.9990577,0.000387271,0.0001162201,0.0001339431,0.0001746365,0.0001302675],"domain_scores_gemma":[0.9971467,0.001975352,0.0002360706,0.00009444702,0.0002174274,0.000330069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.001933224,0.000389797,0.07052372,0.0003289213,0.0002647344,0.2139993,0.0007568651,0.0009208102,0.002344499,0.01576631,0.5829971,0.1097747],"study_design_scores_gemma":[0.001744481,0.00127052,0.05575869,0.0006416864,0.0004767729,0.3727475,0.001414065,0.005838776,0.002050173,0.04445092,0.5134584,0.0001479268],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04457391,0.004381526,0.0006200998,0.9237581,0.005288224,0.00002595307,0.0001591457,0.00005416853,0.02113886],"genre_scores_gemma":[0.3796115,0.006769952,0.001651707,0.5131196,0.07719463,0.0000721583,0.0002368969,0.00007903385,0.02126453],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02073812,"threshold_uncertainty_score":0.02070075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0285923259317923,"score_gpt":0.3370671022515641,"score_spread":0.3084747763197718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}