{"id":"W2147853500","doi":"10.1016/j.jmb.2005.05.046","title":"A Structure-based Model of the c-Myc/Bin1 Protein Interaction Shows Alternative Splicing of Bin1 and c-Myc Phosphorylation are Key Binding Determinants","year":2005,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Natural Sciences and Engineering Research Council; Ontario Institute for Cancer Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation; Cancer Research Institute","keywords":"Biology; Alternative splicing; Gene isoform; SH3 domain; Phosphorylation; RNA splicing; Binding site; Binding domain; WW domain; Transcription factor; Plasma protein binding; Cell biology; Molecular biology; Biochemistry; Gene; Proto-oncogene tyrosine-protein kinase Src; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001277385,0.0008736145,0.001145444,0.0003409422,0.001436651,0.001218293,0.001579577,0.001992042,0.01229496],"category_scores_gemma":[0.0002199322,0.0005498726,0.0006337388,0.0005379438,0.0006243355,0.0008814722,0.000463421,0.001353171,0.00143279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001262862,"about_ca_system_score_gemma":0.001170086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01085876,"about_ca_topic_score_gemma":0.008718503,"domain_scores_codex":[0.9999217,0.00001115285,0.000002874677,0.00001701578,0.00002222591,0.00002512742],"domain_scores_gemma":[0.9999127,0.00002641469,0.00001097262,0.000006879278,0.00001523286,0.00002769057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001451393,0.0004572133,0.001603914,0.00043552,0.0001426094,0.001524456,0.0003745973,0.7836099,0.07959024,0.1082484,0.009847123,0.01271466],"study_design_scores_gemma":[0.0002439856,0.0001085352,0.001062084,0.00002010456,0.00004823423,0.0001583982,0.00007995431,0.9627075,0.003775652,0.02718569,0.004569228,0.00004057502],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8018279,0.002726467,0.1143612,0.006110155,0.0005405818,0.0001748541,0.003931001,0.003339893,0.06698802],"genre_scores_gemma":[0.9729825,0.0007563057,0.01867074,0.0003024593,0.00003624739,0.0001104889,0.001139882,0.0002277582,0.005773596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01229496,"threshold_uncertainty_score":0.04113078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408979353069389,"score_gpt":0.2925320225676612,"score_spread":0.2784422290369673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}