{"id":"W2147853500","doi":"10.1016/j.jmb.2005.05.046","title":"A Structure-based Model of the c-Myc/Bin1 Protein Interaction Shows Alternative Splicing of Bin1 and c-Myc Phosphorylation are Key Binding Determinants","year":2005,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Natural Sciences and Engineering Research Council; Ontario Institute for Cancer Research; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation; Cancer Research Institute","keywords":"Biology; Alternative splicing; Gene isoform; SH3 domain; Phosphorylation; RNA splicing; Binding site; Binding domain; WW domain; Transcription factor; Plasma protein binding; Cell biology; Molecular biology; Biochemistry; Gene; Proto-oncogene tyrosine-protein kinase Src; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003018995,0.0001374356,0.0002620013,0.0001365829,0.00004900452,0.00001004147,0.0002196335,0.0001473671,0.000003441599],"category_scores_gemma":[0.0001775312,0.00009706092,0.0001378591,0.00008636017,0.00007062187,0.00001201721,0.00009120469,0.0002086954,1.694954e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007404012,"about_ca_system_score_gemma":0.000109281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003346905,"about_ca_topic_score_gemma":0.0001077072,"domain_scores_codex":[0.9988613,0.0001584692,0.0004506156,0.0001762934,0.0001655906,0.0001876947],"domain_scores_gemma":[0.9986632,0.00001955316,0.0008086493,0.0001909794,0.0002549408,0.00006267194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002992765,0.00003437213,0.003749606,0.00002909417,0.00006351193,0.00000295095,0.00004326691,0.008851099,0.9832531,0.00001631758,0.00001094201,0.003646515],"study_design_scores_gemma":[0.0007335581,0.0004325281,0.0003226531,0.0001373026,0.00002297304,0.00003747668,0.00004003245,0.02142575,0.9765785,0.000140043,0.00004092209,0.00008823339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873554,0.000277863,0.01173339,0.000336326,0.00005837803,0.0002008829,0.0000249348,0.000001280005,0.0000115623],"genre_scores_gemma":[0.9977817,0.00004332483,0.001955573,0.00007002254,0.00007871987,0.000002987699,0.000004929055,0.00001464887,0.00004808175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01257465,"threshold_uncertainty_score":0.3958029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408979353069389,"score_gpt":0.2925320225676612,"score_spread":0.2784422290369673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}