{"id":"W2147859079","doi":"10.1200/jco.2006.05.9212","title":"Phase II Trial Evaluating the Palliative Benefit of Second-Line Zoledronic Acid in Breast Cancer Patients With Either a Skeletal-Related Event or Progressive Bone Metastases Despite First-Line Bisphosphonate Therapy","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Bone health and treatments","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Dairy Farmers of Canada","keywords":"Medicine; Zoledronic acid; Bisphosphonate; N-terminal telopeptide; Palliative care; Breast cancer; Bone pain; Internal medicine; Urology; Bone remodeling; Oncology; Cancer; Osteoporosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002557979,0.000285492,0.00190515,0.0001432149,0.0001106028,0.000006171764,0.0001407005,0.0002862768,0.0007999289],"category_scores_gemma":[0.0004981878,0.0001319349,0.0004041517,0.0004083856,0.0002385156,0.0001184508,0.00004253567,0.0009690152,0.000003247135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003126157,"about_ca_system_score_gemma":0.002574722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003302662,"about_ca_topic_score_gemma":0.002145745,"domain_scores_codex":[0.9945415,0.0005152129,0.00358353,0.0002808571,0.000661362,0.0004175472],"domain_scores_gemma":[0.9926904,0.001307847,0.004617939,0.0002106255,0.000917558,0.0002556395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5502387,0.04557985,0.06853128,0.00005931113,0.001693329,0.0004129262,0.0002773044,0.0002591636,0.00003204123,0.00001081206,0.0001469406,0.3327583],"study_design_scores_gemma":[0.4734312,0.2339921,0.2882096,0.000630811,0.0009272827,0.0000928352,0.00002628413,0.0003815284,0.0001756818,0.000268318,0.001712363,0.0001519598],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887817,0.004531686,0.000007003893,0.00424375,0.0004755749,0.001802312,0.0001252115,0.000007420271,0.00002536229],"genre_scores_gemma":[0.9969975,0.000983663,0.0005641298,0.0008159844,0.0002175231,0.0001114279,0.00002826121,0.00003474176,0.0002467442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3326063,"threshold_uncertainty_score":0.8758661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09509900927046033,"score_gpt":0.4882822545423567,"score_spread":0.3931832452718964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}