{"id":"W2147881857","doi":"10.1136/bmjopen-2013-002759","title":"Study protocol for a randomised controlled double-blinded trial of the dose-dependent efficacy and safety of primaquine for clearance of gametocytes in children with uncomplicated falciparum malaria in Uganda","year":2013,"lang":"en","type":"article","venue":"BMJ Open","topic":"Malaria Research and Control","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; International Development Research Centre; Wellcome Trust; London School of Hygiene and Tropical Medicine","keywords":"Primaquine; Gametocyte; Medicine; Malaria; Artemether/lumefantrine; Plasmodium falciparum; Artemisinin; Placebo; Pharmacology; Clinical endpoint; Haemolysis; Plasmodium vivax; Internal medicine; Clinical trial; Chloroquine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02861836,0.007533724,0.01176876,0.001732967,0.004092485,0.003874419,0.003780379,0.009066991,0.1206189],"category_scores_gemma":[0.02904006,0.003981508,0.004235409,0.002583438,0.005352268,0.003759096,0.002120159,0.01125014,0.0235413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003298553,"about_ca_system_score_gemma":0.01435897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293337,"about_ca_topic_score_gemma":0.003109996,"domain_scores_codex":[0.9779926,0.01283116,0.002045763,0.003072131,0.002034302,0.002024145],"domain_scores_gemma":[0.9836858,0.003618933,0.003201864,0.002753658,0.002879904,0.00385979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9527918,0.005635217,0.0005082202,0.009502268,0.0008623173,0.0001689765,0.0002197512,0.00051759,0.001507855,0.003408452,0.0112881,0.01358945],"study_design_scores_gemma":[0.9464733,0.02360731,0.0008523045,0.001576075,0.0004892058,0.00005252235,0.00004818398,0.0007473294,0.0004058903,0.001347915,0.02432883,0.00007116311],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.002489932,0.0004135046,0.001652637,0.0002306532,0.0009866373,0.9910154,0.001653154,0.0001378498,0.001420279],"genre_scores_gemma":[0.003621174,0.0002104935,0.002146286,0.0003444452,0.0001852719,0.9921706,0.0003164003,0.000012136,0.0009931753],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1206189,"threshold_uncertainty_score":0.4035103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07931376888128962,"score_gpt":0.4199548147525468,"score_spread":0.3406410458712572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}