{"id":"W2147888714","doi":"10.1172/jci43910","title":"Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation","year":2010,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Fondation Leducq; Howard Hughes Medical Institute","keywords":"Noonan syndrome; Guanine nucleotide exchange factor; Mutation; Biology; Mutant; Phenotype; Signal transduction; Genetics; MAPK/ERK pathway; Cancer research; Costello syndrome; Positional cloning; Cell biology; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002866056,0.001158866,0.0003143166,0.00110089,0.000306703,0.0003827444,0.0004064082,0.0006936577,0.00265024],"category_scores_gemma":[0.0002413255,0.0005180012,0.0004504604,0.0002083097,0.0006916285,0.0002681607,0.000442811,0.0009603726,0.0005452021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004688726,"about_ca_system_score_gemma":0.0003462807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000938901,"about_ca_topic_score_gemma":0.002177483,"domain_scores_codex":[0.9995741,0.00007673843,0.00005378599,0.0001058454,0.0001149566,0.00007461992],"domain_scores_gemma":[0.9996102,0.00006693321,0.0001218638,0.00002120968,0.00001399029,0.0001658315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004472258,0.0001417205,0.00070331,0.00004128897,0.00001503462,0.0007335437,0.00005257598,0.0001894002,0.9955053,0.0003933642,0.0001310482,0.001646046],"study_design_scores_gemma":[0.0004797482,0.001759476,0.02550978,0.0000925049,0.000128373,0.005799036,0.0002146545,0.007829286,0.9500182,0.0007163812,0.007404603,0.0000479464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951594,0.0004649303,0.001742678,0.0002158239,0.00003760729,0.00004016851,0.000728155,0.0001582153,0.001452932],"genre_scores_gemma":[0.9899362,0.0008153937,0.003411814,0.0001128304,0.00002092424,0.00009248803,0.0006865321,0.00007257448,0.004851277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00265024,"threshold_uncertainty_score":0.008865893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03948592687049474,"score_gpt":0.298727465877662,"score_spread":0.2592415390071673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}