{"id":"W2147893564","doi":"10.1016/j.jalz.2014.05.362","title":"P1‐125: DETERMINING THE OLIGOMERIC STATE OF THE BETA‐SITE APP‐CLEAVING ENZYME 1 (BACE1) IN NATURAL MEMBRANES AND DETERGENTS","year":2014,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Förster resonance energy transfer; Peptide; Amyloid precursor protein; Ectodomain; Metal ions in aqueous solution; Membrane; Peptide sequence; Stereochemistry; Biochemistry; Biophysics; Metal; Fluorescence; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002463063,0.0004309228,0.0002021988,0.0001564727,0.0001819775,0.0003565018,0.0002680787,0.0003409307,0.0006528625],"category_scores_gemma":[0.0004253502,0.0001743353,0.0001540331,0.0001656166,0.0002359819,0.0002876261,0.0002171492,0.000475321,0.0002780355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002882094,"about_ca_system_score_gemma":0.0001217926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006435712,"about_ca_topic_score_gemma":0.00047378,"domain_scores_codex":[0.9997973,0.00006633403,0.00001813885,0.00005219749,0.00003836905,0.00002770779],"domain_scores_gemma":[0.9998577,0.00006073008,0.00003066055,0.00001015864,0.00001887771,0.00002190989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004502775,0.00001939958,0.0000974565,0.00002272384,0.000003412268,0.00001922584,0.00002879485,0.00005778436,0.999278,0.00004036038,0.00001455079,0.0003732302],"study_design_scores_gemma":[0.00001431764,0.0002782927,0.003628013,0.00001250488,0.00001544895,0.0001859894,0.00005646191,0.00205458,0.9919777,0.00007128943,0.001695708,0.000009705127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957315,0.0008635081,0.002420877,0.00004268463,0.000007380902,0.00003183617,0.0001541589,0.0000209001,0.0007270133],"genre_scores_gemma":[0.9927914,0.0009077768,0.003899213,0.0000442228,0.000008692768,0.00005776581,0.0009127527,0.00001987625,0.001358315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006528625,"threshold_uncertainty_score":0.002183974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835915531561468,"score_gpt":0.2774380152709307,"score_spread":0.259078859955316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}