{"id":"W2147894026","doi":"10.1111/j.1399-0004.2011.01769.x","title":"Skipping along: an exon skipping therapy shows promise for Duchenne muscular dystrophy","year":2011,"lang":"en","type":"letter","venue":"Clinical Genetics","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Duchenne muscular dystrophy; Exon skipping; Morpholino; Medicine; Dystrophin; Muscular dystrophy; Exon; Internal medicine; Genetics; Biology; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005849806,0.0006414347,0.0007837206,0.00007036571,0.0001915076,0.00004749354,0.0009006634,0.002867435,0.00008076095],"category_scores_gemma":[0.0003112831,0.0006121553,0.0008425551,0.00007033033,0.0004503637,0.000006031183,0.000211181,0.001112405,0.00002103096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001231554,"about_ca_system_score_gemma":0.0002623592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001282047,"about_ca_topic_score_gemma":0.00001623805,"domain_scores_codex":[0.9960418,0.0004300353,0.001039551,0.001497856,0.000185433,0.0008053076],"domain_scores_gemma":[0.9973558,0.0001283742,0.0004554129,0.001564088,0.0002780737,0.0002182943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002275899,0.001447292,0.003512555,0.0006597258,0.002071391,0.00009489188,0.0002073227,0.0001309458,0.08390643,0.00004416879,0.8285193,0.07713006],"study_design_scores_gemma":[0.00240583,0.003270483,0.001971981,0.00004706904,0.0001664067,0.000007734304,0.00002417471,0.0001210099,0.004871151,0.001028855,0.9850712,0.001014077],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.9635228,0.007741306,0.005680822,0.01604587,0.003026946,0.002972628,0.0002575083,0.0001056156,0.0006465124],"genre_scores_gemma":[0.2012743,0.01305843,0.0187437,0.7110891,0.04030268,0.001124464,0.01077435,0.0007726633,0.002860304],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7622485,"threshold_uncertainty_score":0.999633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09939083493180677,"score_gpt":0.3527381928590215,"score_spread":0.2533473579272147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}