{"id":"W2147894026","doi":"10.1111/j.1399-0004.2011.01769.x","title":"Skipping along: an exon skipping therapy shows promise for Duchenne muscular dystrophy","year":2011,"lang":"en","type":"letter","venue":"Clinical Genetics","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Duchenne muscular dystrophy; Exon skipping; Morpholino; Medicine; Dystrophin; Muscular dystrophy; Exon; Internal medicine; Genetics; Biology; Alternative splicing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007376612,0.0004753049,0.0008826258,0.000414924,0.0005334299,0.0006483495,0.000503798,0.00476741,0.004286201],"category_scores_gemma":[0.002166893,0.0001341877,0.0008128254,0.0002325354,0.0007776876,0.001113932,0.0003385811,0.005243249,0.002668384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008043281,"about_ca_system_score_gemma":0.0004716689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005699234,"about_ca_topic_score_gemma":0.001802741,"domain_scores_codex":[0.9995499,0.0001087784,0.00005221893,0.00007650771,0.0001559576,0.00005664042],"domain_scores_gemma":[0.999263,0.0004311436,0.00006078559,0.00003133209,0.0001035018,0.0001102643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001558929,0.00027076,0.002168268,0.0008701102,0.00008489079,0.02466218,0.0001594312,0.0001838181,0.005528806,0.006643644,0.6766382,0.2812309],"study_design_scores_gemma":[0.001103051,0.001241688,0.005659622,0.0009411449,0.0001275502,0.03933907,0.0001214409,0.0004337471,0.002129742,0.009363248,0.9394766,0.00006306035],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01604873,0.1605981,0.002128091,0.7423437,0.04830156,0.0001679667,0.0003786701,0.0003482682,0.02968496],"genre_scores_gemma":[0.07589737,0.1070138,0.003321211,0.6662703,0.08949941,0.0002477662,0.0003863804,0.0001191382,0.05724461],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.00476741,"threshold_uncertainty_score":0.01433879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09939083493180677,"score_gpt":0.3527381928590215,"score_spread":0.2533473579272147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}