{"id":"W2147917643","doi":"10.4161/cc.26461","title":"Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer","year":2013,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Università degli Studi di Genova","keywords":"Biology; Hexokinase; Metformin; Breast cancer; Carbohydrate metabolism; Metabolism; Glycolysis; Cancer research; Cancer; Cell biology; Endocrinology; Internal medicine; Biochemistry; Diabetes mellitus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252603,0.0003609502,0.0003957747,0.0002646993,0.0001528485,0.0002179218,0.000205177,0.0001723625,0.001351561],"category_scores_gemma":[0.000102959,0.0001680841,0.0002185721,0.0002338978,0.0001606912,0.0001727375,0.000130326,0.000557888,0.0002362076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003466698,"about_ca_system_score_gemma":0.0003583171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001197771,"about_ca_topic_score_gemma":0.002368324,"domain_scores_codex":[0.9998796,0.00002264118,0.00001318559,0.00001654054,0.00003009619,0.00003792603],"domain_scores_gemma":[0.9999307,0.00001307602,0.00001984355,0.00001069969,0.00000533984,0.00002028516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006728129,0.0001608231,0.0003184579,0.0000405363,0.000007385222,0.00003522758,0.00001254257,0.00006809729,0.9963095,0.00007986826,0.00005154263,0.002243177],"study_design_scores_gemma":[0.00003713022,0.001206302,0.003493203,0.000004392172,0.0000189298,0.0001271543,0.0000188712,0.0004957225,0.9933949,0.00003334422,0.001166723,0.000003182997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951734,0.002426388,0.001077587,0.00008763982,0.00004309546,0.00002723752,0.0003087583,0.00005219616,0.0008037088],"genre_scores_gemma":[0.9916591,0.003248492,0.001566881,0.00005582797,0.00001449034,0.00008592247,0.0007133305,0.0000212839,0.002634593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351561,"threshold_uncertainty_score":0.00452143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004088111859512692,"score_gpt":0.2129731970062386,"score_spread":0.2088850851467259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}