{"id":"W2147959526","doi":"10.1128/jvi.79.23.14507-14515.2005","title":"Akt/Protein Kinase B Activation by Adenovirus Vectors Contributes to NFκB-Dependent CXCL10 Expression","year":2005,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale","keywords":"Biology; Wortmannin; Protein kinase B; LY294002; CXCL10; Signal transduction; Cell biology; PI3K/AKT/mTOR pathway; Reporter gene; Viral vector; Chemokine; Molecular biology; Gene expression; Immunology; Immune system; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002754393,0.0004307154,0.0001597283,0.0002516554,0.0001641941,0.0004428449,0.0001219924,0.0002428389,0.002246098],"category_scores_gemma":[0.00008118086,0.000194061,0.0003756124,0.0001546017,0.0003187392,0.0003512182,0.0001631855,0.0007018938,0.0007394711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003624746,"about_ca_system_score_gemma":0.0004463022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004368702,"about_ca_topic_score_gemma":0.0005316379,"domain_scores_codex":[0.9998333,0.00002204522,0.000016999,0.0000283724,0.00005882286,0.00004025278],"domain_scores_gemma":[0.9999131,0.00001164529,0.00002879387,0.000008641595,0.00001745838,0.00002038709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001722965,0.00008080782,0.0005075556,0.0001678119,0.000006746433,0.00007079144,0.00002729607,0.00009130104,0.9929188,0.0005448749,0.0001400662,0.005271591],"study_design_scores_gemma":[0.00005490562,0.0003519344,0.01198156,0.00005442905,0.00003657705,0.0007446992,0.00009708267,0.002273938,0.9625299,0.0005581343,0.02130362,0.00001316289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9490246,0.01680411,0.02287635,0.0008399945,0.0003235567,0.0001288591,0.0009357219,0.0002990506,0.008767718],"genre_scores_gemma":[0.9714382,0.01110841,0.009311559,0.0001383921,0.00003967377,0.00008098638,0.0009714098,0.00002775355,0.00688356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002246098,"threshold_uncertainty_score":0.007514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005795569208567,"score_gpt":0.2890914300907725,"score_spread":0.2790334743986869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}