{"id":"W2147961966","doi":"10.1016/j.tig.2006.04.010","title":"Epigenetics and twins: three variations on the theme","year":2006,"lang":"en","type":"article","venue":"Trends in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute of Mental Health","keywords":"Biology; Epigenetics; Phenotype; Genetics; Heritability; Trait; Twin study; Missing heritability problem; Evolutionary biology; Population; Gene; Epigenesis; Quantitative trait locus; DNA methylation; Genetic variants; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004042236,0.0003400125,0.001186073,0.001367016,0.001192909,0.002496203,0.0009112768,0.002246569,0.002751206],"category_scores_gemma":[0.01348058,0.0003233557,0.0004837374,0.001402111,0.005367709,0.002494093,0.00383029,0.00226142,0.0001866964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009171234,"about_ca_system_score_gemma":0.001018494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002507938,"about_ca_topic_score_gemma":0.002908362,"domain_scores_codex":[0.9968818,0.00140843,0.0001747246,0.0006242329,0.0006874306,0.0002232946],"domain_scores_gemma":[0.9957081,0.002578736,0.0003951072,0.0004376281,0.0004550072,0.0004254478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002104626,0.0002351323,0.1523345,0.0009555674,0.001105446,0.00434155,0.03989981,0.0003468768,0.01878984,0.4743209,0.0126285,0.2929372],"study_design_scores_gemma":[0.0002563712,0.0004333617,0.186528,0.001840781,0.00128313,0.01680814,0.02760501,0.001704004,0.005305844,0.676704,0.08119721,0.0003342136],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6400484,0.1534803,0.03710261,0.1365107,0.004742005,0.0001292398,0.0006106378,0.0001275817,0.02724843],"genre_scores_gemma":[0.9310479,0.0356709,0.01002234,0.01410547,0.002877705,0.0001278597,0.0001406382,0.00008271399,0.005924503],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004042236,"threshold_uncertainty_score":0.02137768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191561458633902,"score_gpt":0.2686285621064498,"score_spread":0.2467129475201107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}