{"id":"W2147961966","doi":"10.1016/j.tig.2006.04.010","title":"Epigenetics and twins: three variations on the theme","year":2006,"lang":"en","type":"article","venue":"Trends in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute of Mental Health","keywords":"Biology; Epigenetics; Phenotype; Genetics; Heritability; Trait; Twin study; Missing heritability problem; Evolutionary biology; Population; Gene; Epigenesis; Quantitative trait locus; DNA methylation; Genetic variants; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122229,0.0001591789,0.0001020105,0.00009275413,0.00009973923,0.00003717837,0.0001633198,0.0001363129,0.00003753456],"category_scores_gemma":[0.00003127192,0.0001251334,0.00004666977,0.0001945358,0.00008667697,0.000001279506,0.00008121096,0.00009771068,0.000005921405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000011263,"about_ca_system_score_gemma":0.00001990872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005399368,"about_ca_topic_score_gemma":0.001024989,"domain_scores_codex":[0.9990337,0.00006264541,0.0002408278,0.000292549,0.0001458644,0.0002243999],"domain_scores_gemma":[0.999378,0.00004390428,0.00006842074,0.0004332059,0.00004004314,0.00003640236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009719138,0.0006203792,0.2305898,0.0000196116,0.0001014204,0.000008104075,0.0002808976,0.01908186,0.5189046,0.04416923,0.003784967,0.182342],"study_design_scores_gemma":[0.0007599389,0.0004619062,0.7792614,0.00001294331,0.0000341118,0.000002400222,0.00002994398,0.00315506,0.1568611,0.01699247,0.04201242,0.000416248],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828061,0.003608546,0.002925622,0.0006672856,0.0001216702,0.0001223201,0.00002111322,0.000009715054,0.009717593],"genre_scores_gemma":[0.9965339,0.000578345,0.001588747,0.0001373091,0.0002652062,0.00002205834,0.00007731248,0.00002535218,0.000771763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5486717,"threshold_uncertainty_score":0.5102792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191561458633902,"score_gpt":0.2686285621064498,"score_spread":0.2467129475201107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}