{"id":"W2147990519","doi":"10.1128/aac.44.11.3049-3054.2000","title":"Fluoroquinolone Resistance in Clinical Isolates of <i>Streptococcus pneumoniae</i> : Contributions of Type II Topoisomerase Mutations and Efflux to Levels of Resistance","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; University Health Network; University of Toronto; Dalhousie University; Hamilton Health Sciences; McMaster University","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Efflux; Ciprofloxacin; Biology; Microbiology; Streptococcus pneumoniae; Topoisomerase IV; Amino acid substitution; Quinolone; Amino acid; Cross-resistance; Streptococcaceae; Mutation; DNA gyrase; Genetics; Gene; Antibiotics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002545624,0.0003167439,0.0003109874,0.0004930762,0.0001831487,0.0005169656,0.0001536094,0.0004017448,0.0005250628],"category_scores_gemma":[0.002225457,0.0001674377,0.0001118719,0.0004217706,0.0003335477,0.0001771534,0.0001316112,0.0002546757,0.0002086293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003272253,"about_ca_system_score_gemma":0.0001998072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002154002,"about_ca_topic_score_gemma":0.00194945,"domain_scores_codex":[0.9994418,0.0001477834,0.00008170284,0.00009961244,0.0001393697,0.00008968409],"domain_scores_gemma":[0.9987888,0.000381237,0.0004629694,0.00004930142,0.0001940502,0.0001236837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001292578,0.0001252837,0.861164,0.0001726392,0.0001082707,0.0009473294,0.0005305836,0.0002667093,0.1215523,0.00003723582,0.0002300716,0.01357302],"study_design_scores_gemma":[0.000024528,0.001008297,0.9674832,0.00001647112,0.0000803885,0.005303724,0.000334684,0.0003881036,0.02461103,0.00003764719,0.0006963244,0.00001555717],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999276,0.0004056515,0.00006584596,0.00001930851,0.000001239856,0.000004405384,0.00008327958,0.00000530532,0.000139048],"genre_scores_gemma":[0.9993998,0.0001576264,0.0001769532,0.00001378438,0.000004992839,0.000003903355,0.0001952263,0.000002304502,0.00004533976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002154002,"threshold_uncertainty_score":0.004282892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683226412214952,"score_gpt":0.3138974713780354,"score_spread":0.2970652072558859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}