{"id":"W2148014324","doi":"10.1534/genetics.108.088914","title":"Histone H3 K56 Hyperacetylation Perturbs Replisomes and Causes DNA Damage","year":2008,"lang":"en","type":"article","venue":"Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Center for Research Resources; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Histone; Genetics; Replisome; DNA; DNA damage; DNA replication; Histone H2A; Cell biology; Circular bacterial chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007904143,0.0004407919,0.0002387003,0.0002310394,0.0001715447,0.00022339,0.0002454029,0.0002279718,0.001581042],"category_scores_gemma":[0.0000972765,0.0001934845,0.0002762582,0.000198417,0.0002811036,0.0001201603,0.000346819,0.000396695,0.0003767377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003695831,"about_ca_system_score_gemma":0.0001826901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097944,"about_ca_topic_score_gemma":0.001107119,"domain_scores_codex":[0.999844,0.00002067839,0.0000190914,0.00003449875,0.00004268885,0.00003914601],"domain_scores_gemma":[0.9998558,0.00001469119,0.00005287468,0.00002849512,0.00000774728,0.00004036593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005535029,0.00000646439,0.0001151267,0.000007761065,0.000003658607,0.00003341839,0.00000383035,0.00003707084,0.9994879,0.00002342943,0.000009960634,0.000215934],"study_design_scores_gemma":[0.000005566332,0.00007489672,0.00249989,0.000001684012,0.000006478752,0.0001665004,0.00001032037,0.0003501769,0.9963264,0.00002081168,0.0005347971,0.000002306933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970259,0.0003933268,0.001397756,0.00004913192,0.00001764789,0.000008888324,0.0003297226,0.0000815579,0.0006961563],"genre_scores_gemma":[0.9974967,0.0002494087,0.0006169323,0.00002214608,0.000004021559,0.000008890359,0.0004304898,0.00002741366,0.001144062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001581042,"threshold_uncertainty_score":0.005289137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037343903173716,"score_gpt":0.2320206572909988,"score_spread":0.2216472182592617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}