{"id":"W2148014324","doi":"10.1534/genetics.108.088914","title":"Histone H3 K56 Hyperacetylation Perturbs Replisomes and Causes DNA Damage","year":2008,"lang":"en","type":"article","venue":"Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Center for Research Resources; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Histone; Genetics; Replisome; DNA; DNA damage; DNA replication; Histone H2A; Cell biology; Circular bacterial chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005682988,0.0001387101,0.0001164311,0.00002894112,0.0001489039,0.0000171262,0.000105679,0.0001257318,0.0000120642],"category_scores_gemma":[0.00003343936,0.0001430099,0.0000409553,0.00004286386,0.0001112473,0.00000221386,0.0001120188,0.00005554092,0.000007156014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001466632,"about_ca_system_score_gemma":0.00005060998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007947855,"about_ca_topic_score_gemma":0.0000460813,"domain_scores_codex":[0.9992516,0.00002256744,0.0001685174,0.0002895283,0.00008947349,0.000178293],"domain_scores_gemma":[0.9994252,0.000007809797,0.00006413604,0.0003677504,0.00005981428,0.00007528351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001601066,0.0000441269,0.01262248,0.00001967132,0.00003590069,0.000008574849,0.0002608423,0.0002536115,0.9816183,0.00006025311,0.003851061,0.001209158],"study_design_scores_gemma":[0.002076461,0.0008860322,0.4260344,0.00002238674,0.0001086683,0.0006600171,0.000380664,0.0069719,0.3606336,0.0004201724,0.2004706,0.001335087],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967139,0.001963078,0.000330694,0.0001288625,0.0001091107,0.0001016666,0.00002143663,0.00001333919,0.0006179533],"genre_scores_gemma":[0.9901609,0.002623336,0.004995759,0.0002281611,0.0001655328,0.000006340651,0.0001393103,0.00002860313,0.001652053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6209847,"threshold_uncertainty_score":0.5831774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037343903173716,"score_gpt":0.2320206572909988,"score_spread":0.2216472182592617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}